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Application Notes

 
Automated Sample Preparation of 25-OH-Vitamin D3/D2 from Serum with the AC Extraction Plate and the Tecan Freedom EVO® for the quantification by LC-MS/MS
Application Note

Tecan Group Ltd.

There is an increasing demand for the determination of Vitamin D status which is based on the quantification of the two metabolites 25-OH-Vitamin D3/D2. Numerous laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) because of its specificity combined with high sensitivity. Moreover LC-MS/MS offers the potential for multianalyte determination which is required for Vitamin D status determination.

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Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Application Note

Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.

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Colony Picking - fully automated screening of fungi
Application Note

Tecan Group Ltd.

Manual screening processes are very costly and time consuming. This ambitious project for high throughput screening (HTS) of cellulase-producing fungal strains demonstrates the high capacity and unique features of the Freedom EVO colony picking workstation. The picking of fungi is more complex than for typical bacterial colonies, and requires advanced selection criteria to be combined with complex pipetting and a tip movement that mimics the manual picking process.

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Trends, Challenges and Strategy in the Forensic Science Sector
Application Note

The forensic science sector is in transition. New insights, technologies, and customers, combined with falling costs and increasing capabilities cause the sector to grow rapidly. As a consequence the role of forensic laboratories is changing.

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The Analysis of Common Drugs of Abuse in an Oral Fluid Matrix using a New Q TRAP® Platform
Application Note

SCIEX

The multiplexing analysis of several compound classes, such as common prescription drugs along with drugs of abuse is very important. The measurement of these drugs has generally been performed using urine as the sample matrix. However, many research laboratories are finding the need to analyze these compounds in oral fluid matrices.

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Quantification of Ethylglucuronide in hair by Liquid Chromatography Tandem Mass Spectrometry
Application Note

SCIEX

An advantage of the use of ethylglucuronide (ETG) in hair is that it is not subject to the effect of bacteria. It also offers the opportunity to extend the window of detection up to 6 months compared to hours- days in blood and urine.

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Can LC-MS/MS Be Used in Horse Meat Detection?
Application Note

SCIEX

Following the Food Standards Agency’s announcement that horse and pig DNA had been identified in beef products sold by several supermarket chains, further testing has revealed widespread incidences of such contamination. This application note details a rapid, robust, sensitive and specific LC-MS/MS assay for the simultaneous detection of horse meat and the banned substance phenylbutazone (BUTE).

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Advanced Automated Library Searching for Compound Identification in Forensic Toxicology Samples
Application Note

SCIEX

LC-MS/MS utilization in forensic toxicology screening for drugs and drug metabolites has become increasingly popular due to the selectivity, sensitivity and the speed of LC-MS/MS analysis. MS/MS confirmation with automated searching against available spectral libraries has proven to add a superior level of confidence to the compound identification.

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A Complete Forensic Toxicology Screening Procedure for Drugs and Toxic Compounds in Urine and Plasma Using LC-MS/MS
Application Note

Thermo Fisher Scientific

Implementation of liquid chromatography-mass spectrometry (LC-MS) for forensic toxicology screening provides specific and sensitive analysis of drugs and toxic substances.

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Performance Evaluation of a Thermal Desorption System for Detection of Basic Drugs in Forensic Samples by GC/MS
Application Note

Stir bar sorptive extraction (SBSE) is an innovative sample extraction technique that can be used to process blood, urine, and tissue samples for routine drug screening in the forensic toxicology laboratory.

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