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Does Syringe Filtration Impact Recovery of Cannabinoids Prior to Potency Testing?

To ensure consumer safety, cannabis and cannabis-derived products are extensively tested; this includes mandatory potency testing to identify and quantify tetrahydrocannabinol (THC) and other cannabinoids, like cannabidiol (CBD).

To protect analytical instrumentation during potency testing by HPLC, particulate components must be removed from the sample after extraction, for example using syringe filters. However, with filtration, the test results can be affected by contact between the sample and the filter membrane material.

In this application note, discover whether syringe filters can be used to successfully quantify cannabinoids, with details on:

  • Interfering leachables
  • Recovery rate
  • Differences between filter membrane materials