Toxtyper™ – a Comprehensive LC-MSn Screening Solution for Clinical and Forensic Toxicology

Abstract
A major task for clinical and routine toxicology screening is the reliable, fast and comprehensive identification of drugs and drugs of abuse (DOA). Current techniques such as GC-MS, LC-UV/DAD and immunoassays have several limitations. Liquid chromatography tandem mass spectrometry (LC-MS/MS) is an emerging technology that is more specific than immunoassays, provides more information than LC-UV/DAD detection, and covers a broader range of compounds than GC-MS. Here we describe a robust and automated screening solution based on the latest LC-MSn ion trap technology that promises to provide a combination of the highest performance LC-MS/MS and easy-to-use screening with the greatest transferability of results from lab to lab.