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Cryo-EM and CX-MS: The Power Couple of Proteomics
Article

An ambitious new workflow has married two cutting-edge proteomic analysis techniques to improve imaging of large protein assemblies. The combination of electron cryo-microscopy (cryo-EM) and cross-linking coupled mass spectrometry (CX-MS) allows deeper interrogation of protein structures to a level of detail that the techniques are incapable of obtaining on their own.

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How to Tell “Fake” Olive Oils from the Genuine Article
Article

With olive oil’s popularity on the increase in recent years, olive oil production and sales have become big business. However, it also opens the industry up to fraudsters looking to profiteer from this trend. To tackle this problem, scientists have been exploiting differences at the chemical level to expose adulterated products.

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Metagenomics: Exploring Microbiomes at Nature’s New Frontiers
Article

Advances in sequencing technologies are providing scientists with a powerful way to view microbial communities in unprecedented detail. Metagenomics is a rapidly evolving field that is uncovering a wealth of hidden biodiversity, revolutionizing our understanding of uncharted corners in the living world.

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Sensitive Quantification of Drug Metabolites Using LC-MS
Article

Determining what happens to a drug after it enters the body is a key consideration in the drug development process. Liquid chromatography coupled with mass spectrometry (LC-MS) has emerged as one of the most powerful analytical tools for the screening and identification of drug metabolites. Advances in the field of LC-MS have allowed scientists to analyze drug metabolic pathways and drug-drug interactions more closely, and improve therapeutic strategies for many challenging diseases.

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Tech Solutions for Drinking Water Analysis
Article

Improved access to clean and safe drinking water is key for health and survival and has been classified as a human right. Here, we take a look at some of the novel solutions, both hi-tech and low-tech, that scientists are designing to help monitor drinking water source safety.

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Unease on the High Seas: The Effect of Climate Change on Marine Microbial Ecology
Article

Microbes play an important role in the marine ecosystem, however, the effects of climate change have the potential to upset this fine balance, leading to increasing issues with cyanobacterial blooms. Exciting work seeks to look at the knock on effects on the marine food web and ways to combat these toxic blooms.

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Chemotyping: Classifying cannabis strains by chemical composition
Article

Grouping strains by chemotyping may prove useful in ascertaining how strains are related, and the kind of medical benefits you can expect to see with strains from a given chemotype class.

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Making Laser Spectroscopy Portable for On-Site Food Safety Tests
Article

Those involved in the production, processing and distribution of food know that food safety is not an issue to be taken lightly. Of note, mycotoxins in food are subject to strict legislative limits and therefore their detection and quantification are a key area of interest.

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Why Gold Nanoparticles Offer a Bright Future for Diagnostics and Healthcare
Article

Today, nanoparticle research is one of the fastest-growing scientific fields, and one in which exciting new discoveries abound.

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Mass Spectrometry Based Analysis Reveals the Chemistry of Wine Bouquet
Article

Scientists have developed an automated dynamic headspace method that can provide a snapshot of the aroma compounds emanated from wine in conditions close to those found during wine tasting. They have then implemented the technique to see how this profile changes over time as it might in the glass during consumption.

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