Carrots Can Enhance Blood Sugar Regulation, Aiding Diabetes Management

Could an ordinary carrot improve the treatment of type 2 diabetes? A new study from SDU suggests so. The researchers found that carrots can enhance the body's ability to regulate blood sugar and positively influence the composition of gut bacteria.

Type 2 diabetes affects millions worldwide, with numbers on the rise in Denmark and globally. In Denmark alone, the number of cases has more than quadrupled since 1996.

Treatment typically involves dietary changes and medication, though many people experience side effects from common pharmaceuticals. According to researchers from SDU, Odense University Hospital, and the University of Copenhagen, who collaborated on the recently published study, carrots could offer a natural and potentially side-effect-free way to complement existing treatments.

The impact of carrots on blood sugar and gut bacteria

Researchers studied the effects of carrots over 16 weeks using mice induced with type 2 diabetes. The mice were placed on a high-fat diet to mimic an unhealthy human lifestyle. They were divided into two groups: one received a diet supplemented with 10% freeze-dried carrot powder, while the other received a diet without carrots. Both diets were calorie-matched, ensuring the only variable was the bioactive compounds in the carrots. Results showed that the group receiving carrot powder exhibited improved blood sugar regulation, as measured by glucose tolerance tests.

A glucose tolerance test measures how well the body regulates blood sugar after consuming a specified amount of sugar. In this study, mice were given a sugar solution, and their blood sugar levels were measured over time.

– Our study showed that carrots altered the composition of the gut microbiome – the billions of microorganisms living in the gut that play a crucial role in digestion and health. Mice consuming carrots exhibited a healthier balance of gut bacteria, explains project coordinator Morten Kobæk Larsen, associate professor at the Department of Clinical Research, SDU.

Additionally, these mice had more bacteria that produce short-chain fatty acids (SCFAs). These small molecules formed when bacteria break down dietary fibres, help regulate energy metabolism and blood sugar while supporting gut health.

– Everything we eat affects the composition of gut bacteria, Larsen elaborates.

– Consuming carrots shifts the gut bacteria towards a healthier balance, benefiting mice with type 2 diabetes.

How do carrots work?

Carrots contain bioactive compounds that enhance cells' ability to absorb sugar, thereby aiding blood sugar regulation. These bioactive substances, derived from unsaturated fatty acids, are also present in other vegetables from the carrot family, such as parsley, celery, and parsnips.

– We see carrots as a potential component of future dietary strategies for type 2 diabetes, says Lars Porskjær Christensen, professor of analytical chemistry and natural product chemistry at the Department of Physics, Chemistry, and Pharmacy, SDU.

– Other vegetables in the carrot family might have similar properties.

Could carrots help humans?

The researchers are cautious about directly applying their findings to humans.

– Our study used an animal model, and the next step is to conduct clinical trials, they explain. – Such studies are costly, and we are working to secure external funding to conduct a smaller clinical trial with carrots containing relatively high amounts of bioactive compounds. This could pave the way for larger clinical studies including studies in animals with purified bioactive compounds and thereby substantiate the preventive effects of carrots against type 2 diabetes, says Christensen.

Preliminary findings from a similar study on carrots' effects on colon cancer suggest that as little as 30–40 grams of raw or lightly cooked carrots daily could have beneficial effects.

According to the researchers, the concentration of bioactive compounds varies widely among carrot varieties. However, the right variety can provide sufficient doses of these compounds without needing concentrated products. For example, the 'Night Bird' variety, a purple carrot, contains relatively high concentrations of bioactive substances.

Does preparation matter?

Cooking impacts the amount of health-promoting substances, but they do not disappear entirely.

– Even with prolonged frying or boiling, some bioactive compounds remain. However, raw or lightly cooked carrots seem to be the best option to retain as many beneficial compounds as possible, Christensen advises.

Reference: Kobaek-Larsen M, Maschek S, Kolstrup SH, et al. Effect of carrot intake on glucose tolerance, microbiota, and gene expression in a type 2 diabetes mouse model. Clin Translational Sci. 2024;17(12):e70090. doi: 10.1111/cts.70090

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