Current Developments in Forensic Interpretation of Mixed DNA Samples
News Jul 24, 2014
A number of recent improvements have provided contemporary forensic investigations with a variety of tools to improve the analysis of mixed DNA samples in criminal investigations, producing notable improvements in the analysis of complex trace samples in cases of sexual assult and homicide. Mixed DNA contains DNA from two or more contributors, compounding DNA analysis by combining DNA from one or more major contributors with small amounts of DNA from potentially numerous minor contributors. These samples are characterized by a high probability of drop-out or drop-in combined with elevated stutter, significantly increasing analysis complexity. At some loci, minor contributor alleles may be completely obscured due to amplification bias or over-amplification, creating the illusion of additional contributors. Thus, estimating the number of contributors and separating contributor genotypes at a given locus is significantly more difficult in mixed DNA samples, requiring the application of specialized protocols that have only recently been widely commercialized and standardized. Over the last decade, the accuracy and repeatability of mixed DNA analyses available to conventional forensic laboratories has greatly advanced in terms of laboratory technology, mathematical models and biostatistical software, generating more accurate, rapid and readily available data for legal proceedings and criminal cases.
The review article is published in Biomedical Reports and is free to access.
Scientists Decry Lack of Science in ‘Forensic Science’News
Many of the “forensic science” methods commonly used in criminal cases and portrayed in popular police TV dramas have never been scientifically validated and may lead to unjust verdicts, according to a recent article.
Drug Prevalence Means that Even Many Non-Users Have Them on Their FingerprintsNews
Scientists have found that drugs are now so prevalent that 13 per cent of those taking part in a test were found to have traces of class A drugs on their fingerprints - despite never using them.READ MORE
Robotics Takes Mass Spec to the Third DimensionNews
Within the past decade, many advancements have been made in the 3-D market from printing to movies. Now scientists report that by combining a robotic arm and mass spectrometry, they can analyze the surface of irregularly shaped 3-D objects, potentially opening up new branches of forensics and pharmaceutics.READ MORE
Comments | 0 ADD COMMENT
International Conference on Analytical and Bio Analytical Techniques
Oct 31 - Nov 01, 2018