We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Cyanide Exposure Detection
News

Cyanide Exposure Detection

Cyanide Exposure Detection
News

Cyanide Exposure Detection

Credit: Pixabay.
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Cyanide Exposure Detection"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Cyanide exposure can happen occupationally or in low levels from inhaling cigarette smoke — or from being poisoned by someone out to get you. The effects are fast and can be deadly. But because cyanide is metabolized quickly, it can be difficult to detect in time for an antidote to be administered. Now, in an animal study in ACS’ Chemical Research in Toxicology, researchers report a new precise and accurate biomarker of cyanide exposure.

To treat cyanide poisoning, physicians first have to properly diagnose the condition. But symptoms such as dizziness, headaches and low blood pressure could indicate many different illnesses. And current tests for the condition have disadvantages. Directly measuring cyanide levels in samples is not possible in many cases, since it is rapidly cleared from the body. Some indirect markers of the compound are almost as short-lived, while others are also present in foods, such as broccoli, which can confound the analysis. Cyanide is known to react with thiols, which contain sulfur. In addition, evidence suggests that glutathione, an abundant sulfur-containing molecule in the body, could be a first-line of defense against cyanide poisoning. So, Brian Logue and colleagues wondered if a metabolite of glutathione could be a good indication that someone has been around cyanide.


The researchers reacted glutathione with cyanide and found that 2-aminothiazoline-4-oxoaminoethanioc acid (ATOEA) was produced. They then developed a rapid mass spectrometry method to analyze ATOEA in plasma, and saw that they could accurately detect the compound within minutes of exposure in animals. As the level of cyanide increased, so did the level of ATOEA. And when an antidote was given, ATOEA levels decreased. The researchers say that ATOEA also lasts longer in the body than cyanide, allowing more time for detection of this marker following exposure.

This article has been republished from materials provided by the American Chemical Society. Note: material may have been edited for length and content. For further information, please contact the cited source.

Reference
Metabolism of Cyanide by Glutathione To Produce the Novel Cyanide Metabolite 2-Aminothiazoline-4-oxoaminoethanoic Acid. Obed A. Gyamfi, Nesta Bortey-Sam, Sari B. Mahon, Matthew Brenner, Gary A. Rockwood, and Brian A. Logue. Chem. Res. Toxicol., DOI: 10.1021/acs.chemrestox.8b00384.

Advertisement