"Love Hormone" Oxytocin Linked to Improved Bonding in Autism

A team led by Professor Kaat Alaerts (KU Leuven) recruited 40 adult men with autism spectrum disorder to take part in their study.

"In a first stage, we examined the amount of oxytocin produced by the participants themselves. The subjects also filled out several questionnaires," Professor Alaerts explains. "An analysis of the data revealed that the amount of oxytocin found in the subjects' saliva was inversely related to their self-reported attachment issues."

In the second stage of the research, the team examined the long-term effects of administering oxytocin through a nasal spray. This experiment produced remarkable results: the participants who had been given oxytocin for four weeks experienced positive effects until up to a year later.

Less repetition, more attachment

"We divided the 40 participants into an experimental group and a control group. The control group received a placebo for four weeks," says doctoral student Sylvie Bernaerts, who is the first author of the study.

"Over the course of a full year, we also asked the participants to fill out questionnaires on four different occasions. These questionnaires were used to examine the impact of the oxytocin-containing nasal spray on the symptoms of autism."

In terms of social interaction, the researchers found no difference between the experimental group and the control group. But for repetitive behavior (including the need for routines) and attachment, the results were significant: "The people in the experimental group reported far less repetitive behavior and also reported fewer problems with forming close relationships."

This study shows for the first time what the long-term effects are of repeatedly administering oxytocin to people with autism. Professor Alaerts: "Participants who took oxytocin every day for four weeks experienced positive effects until up to a year later. That's a remarkable result."

Further research necessary

For this study, the scientists only selected male participants. This was partly because autism is more prevalent in men, and women's hormonal cycle may influence the test results. Furthermore, oxytocin is already being used to induce labor or breastfeeding in pregnant women or women who have recently given birth, respectively. In other words, there are more factors to take into account in female test subjects.

And what about using oxytocin as a treatment? "As oxytocin is already being used in medicine, you might think that we can start using it quite soon to address attachment issues or to reduce repetitive behavior in people with autism," says Professor Alaerts. But she is quick to temper expectations: "The findings we're presenting today are the result of a first pilot study. A lot of further research needs to be done before oxytocin can be used to treat people with autism."

Reference

Bernaerts et al. (2020) Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up. Molecular Autism. DOI: https://doi.org/10.1186/s13229-020-0313-1

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