Nutmeg’s Hidden Power
News May 10, 2018 | Original Story from the American Chemical Society.
Smelling nutmeg evokes images of fall, pumpkin pie and hot apple cider. But the spice has been used for years in traditional Chinese medicine to treat gastrointestinal illnesses. Now one group reports in ACS’ Journal of Proteome Research that they have figured out how nutmeg helps other organs, specifically the liver.
According to the Food and Agriculture Organization of the United Nations, the world consumes 9,000 tons of nutmeg annually. Nutmeg is the seed of the Myristica fragrans tree, which is commonly found in Indonesia, and has been used to treat asthma, rheumatic pain, toothaches and infections. In the laboratory, researchers have shown that nutmeg can fight hyperlipidaemia, hyperglycemia, heart tissue damage and hepatotoxicity. Inspired by these studies, Xiu-Wei Yang, Frank Gonzalez, Fei Li and colleagues wanted to see how nutmeg prevents damage to the liver.
The researchers used a mouse animal model of liver toxicity to test the mechanism behind nutmeg’s protective effects. Metabolomics analyses showed that nutmeg likely protected against liver damage by restoring the mice to more healthy levels of various lipids and acylcarnitines. Gene expression studies showed that peroxisome proliferator-activated receptor alpha (PPARα) was modulated by nutmeg, and the spice didn’t protect mice from liver injury if the PPARα gene was deleted. In addition, the team found that a specific compound in nutmeg, myrislignan, had a strong protective effect against liver damage.
This article has been republished from materials provided by the American Chemical Society. Note: material may have been edited for length and content. For further information, please contact the cited source.
PPARα Mediates the Hepatoprotective Effects of Nutmeg. Xiao-Nan Yang, Xue-Mei Liu, Jian-He Fang, Xu Zhu, Xiu-Wei Yang, Xue-Rong Xiao, Jian-Feng Huang, Frank J. Gonzalez, and Fei Li. J. Proteome Res., 2018, 17 (5), pp 1887–1897, DOI: 10.1021/acs.jproteome.7b00901.
Restoring the ability to walk following spinal cord injury requires neurons in the brain to reestablish communication pathways with neurons in the spinal cord, Mature neurons, however, are unable to regenerate their axons to facilitate this process. New research in mice shows one potential route to overcome this limitation may be by targeting liver kinase B1 (LKB1) protein.
Pre-Filled Syringes & Injectable Drug Devices Europe
Jan 16 - Jan 17, 2019
Biofuels Conferences 2019 | Bio Energy Meetings | Chemical Engineering Symposiums
Jul 17 - Jul 18, 2019
3rd International Conference and Exhibition on Nanomedicine and Drug Delivery
Mar 13 - Mar 14, 2019
International Conference on Cell and Structural biology
Jul 15 - Jul 16, 2019