Potato Blight Originated in the Andes, Claims Genome Study
New research firmly points the finger at the Andes mountains as the origin of the potato blight pathogen.

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Call it a mystery solved.
North Carolina State University researchers firmly point the finger at the South American Andes Mountains as the place where the Irish potato famine pathogen, Phtytophthora infestans, originated.
In a wide-ranging study of the genetic material found in P. infestans and other members of the Phytophthora species, the NC State researchers provide more evidence that P. infestans spread from South America to North America before wreaking havoc in Ireland in the 1840s. The pathogen still causes late-blight disease on potato and tomato plants around the world.
Much of the study’s evidence compares whole genomes of P. infestans with those of close relative pathogens – Phytophthora andina and Phytophthora betacei – which are only found in South America. The results show that these three species are very similar.
“It’s one of the largest whole-genome studies of not only P. infestans, but also the sister lineages,” said Jean Ristaino, William Neal Reynolds Distinguished Professor of Plant Pathology at North Carolina State University and corresponding author of a paper in PLOS One that describes the study. “By sequencing these genomes and accounting for evolutionary relationships and migration patterns, we show that the whole Andean region is a hot spot for speciation, or where a species splits into two or more distinct species.”
In recent decades, scientists have been split in their theories about the point of origin for P. infestans, with some hypothesizing a Mexico origin rather than a South American origin. Yet, the paper shows distinct differences between P. infestans and the two Mexican pathogen species, P. mirabilis and P. ipomoea.
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Subscribe for FREE“It points out the importance of looking at the center of origin where a host and pathogen have evolved together over thousands of years,” she said. “Climate change is bringing more drought to higher Andean elevations, so we could be losing some of these potatoes before we learn if they could provide resistance to late-blight disease.” Ristaino added that more research is needed to examine wild potato species from the Andes to learn more about host resistance to P. infestans.
“Our data show that there have been more migrations of the pathogen into and out of South America, and the migrations into and out of Mexico are small in comparison,” said Allison Coomber, a former NC State graduate student researcher and lead author of the paper. “We did find there was gene flow from the Andes to Mexico, and also in reverse, because there’s a big Mexican potato breeding program and potatoes have gone into the Andean region in more recent times. But in historic times it was the other way around.”
“Historic P. infestans – the samples collected from 1845-1889 – were the first to diverge from all other P. infestans populations, with modern South American and Mexican populations both showing shared ancestry derived from historic P. infestans,” Ristaino said. “Modern global trade appears to contribute to mixing together the pathogen populations in South America and Mexico.”
Reference: Coomber AL, Saville AC, Carbone I, Martin M, Bieker VC, Ristaino JB. A pangenome analysis reveals the center of origin and evolutionary history of Phytophthora infestans and 1c clade species. PLOS ONE. 2025;20(1):e0314509. doi: 10.1371/journal.pone.0314509
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