Quantitative Trace Analysis of a Broad Range of Antiviral Drugs in Poultry Muscle
News Feb 15, 2012
A liquid chromatography-tandem mass spectrometry method for the analysis of seven antiviral drugs, zanamivir, ribavirin, oseltamivir, oseltamivir carboxylate, amantadine, rimantadine and arbidol, in poultry muscle is reported. The antiviral drugs were extracted from the homogenized poultry muscle sample using methanol. The extract was purified using tandem solid-phase extraction combining a cation exchange cartridge and a phenylboronic acid cartridge. To prevent excessive matrix effects, the analytes were separated from the matrix constituents using a column-switch liquid chromatography system combining a reversed-phase and a Hypercarb analytical column. Detection was carried out using tandem mass spectrometry. The method was fully validated according to 2002/657/EC and proved to be adequate for quantification and confirmation of zanamivir and ribavirin at 10 μg kg(-1), oseltamivir, oseltamivir carboxylate, amantadine and rimantadine at levels below 1.0 μg kg(-1) and for qualitative confirmatory analysis of arbidol at levels below 1 μg kg(-1).
The article is published online in Analytical and Bioanalytical Chemistry and is free to access.
Energy Drinks Pose Health Risk for YoungstersNews
In a nationwide survey of Canadian youth, over half of those who had ever consumed an energy drink had reported experiencing an adverse health event, including rapid heartbeat, nausea, and in rare cases, seizures. Currently, Canadian legislation is meant to prohibit energy drinks from being marketed to children and energy drinks are not recommend to be used by people participating in sporting activities.READ MORE