We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Scientists Pinpoint Brain Region Crucial for Attention Control

A plastic model of the human brain, bisected.
Credit: Robina Weermeijer/ Unsplash
Listen with
Register for free to listen to this article
Thank you. Listen to this article using the player above.

Want to listen to this article for FREE?

Complete the form below to unlock access to ALL audio articles.

Read time: 2 minutes

Researchers at the University of Iowa in a new study have linked a region in the brain to how humans redirect thoughts and attention when distracted. The connection is important because it offers insights into cognitive and behavioral side effects to a technique being used to treat patients with Parkinson’s disease.

The subthalamic nucleus is a pea-sized brain region involved in the motor-control system, meaning our movements. In people with Parkinson’s disease, those movements have been compromised: Researchers believe the subthalamic nucleus, which normally acts as a brake on sudden movement, is exerting too much influence. That overactive brake, researchers think, is what contributes to the tremors and other motor deficiencies associated with the disease.

In recent years, clinicians have treated Parkinson’s patients with deep-brain stimulation, an electrode implanted in the subthalamic nucleus that rhythmically generates electrical signals, causing the brain region to loosen its braking, freeing up movement. The deep brain stimulation system is like a pacemaker for the heart; once implanted, it runs continuously.

“The technique is truly miraculous, frankly,” says Jan Wessel, associate professor in the departments of Psychological and Brain Sciences and Neurology at Iowa. “People come in with Parkinson’s, surgeons turn the electrode on, and their tremor goes away. Suddenly they can hold their hands steady and go play golf. It's one of those blockbuster treatments where, when you see it in action, it really makes you believe in what the neuroscience community is doing.”

Want more breaking news?

Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day.

Subscribe for FREE
Yet some patients treated with deep brain stimulation have been beset by an inability to focus attention and impulsive thoughts, sometimes leading to risky behaviors such as gambling and substance use. Researchers began to wonder: Did the subthalamic nucleus’ role in movement also mean this same brain region may deal with thoughts and impulse control?

Wessel decided to find out. His team designed an experiment gauging the focus of attention of more than a dozen Parkinson’s patients when the deep brain stimulation treatment was either activated or idle. The participants, outfitted with a skull cap to track their brain waves, were instructed to fix their attention on a computer screen while the brain waves in their visual cortex were being monitored. About one in five times, in a random order, the participants heard a chirping sound, meant to divert their visual attention from the screen to the newly introduced audial distraction.

In a 2021 study, Wessel’s group established that brain waves in participants’ visual cortex dropped when they heard a chirp, meaning their attention had been diverted by the sound. By interchanging instances when there was a chirp or no sound, the researchers could see when attention had been diverted, and when the focus of visual attention had been maintained.

The team turned their attention to the Parkinson’s groups for this study. When the deep brain stimulation was idle and the chirp was sounded, the Parkinson’s patients diverted their attention from the visual to the auditory systems—just as the control group had done in the previous study.

But when the chirp was introduced to the Parkinson’s participants with deep brain stimulation activated, those participants did not divert their visual attention.

“We found they no longer can break or suppress their focus of attention in the same way,” says Wessel, the study’s corresponding author. “The unexpected sound happens and they’re still full-on attending to their visual system. They haven’t diverted their attention from the visual.”

The distinction confirmed the subthalamic nucleus’ role in how the brain and body communicate not only with movement—as previously known—but also with thoughts and attention.

“Until now, it was very unclear why those with Parkinson’s disease had issues with thoughts, such as why they performed worse on attention tests,” Wessel says. “Our study explains why: While removing the inhibitory influence of the subthalamic nucleus on the motor system is helpful in treating Parkinson’s, removing its inhibitory influence from nonmotor systems (such as thoughts or attention) can have adverse effects.”

Wessel firmly believes deep brain stimulation should continue to be used for Parkinson’s patients, citing its clear benefits to aiding motor-control functions.

“There may be different areas of the subthalamic nucleus that stop the motor system and that stops the attentional system,” he says. “That's why we're doing the basic research, to find out how do we fine-tune it to get the full benefit to the motor system without accruing any potential side effects.”

Reference: Soh C, Hervault M, Chalkley NH, et al. The human subthalamic nucleus transiently inhibits active attentional processes. Brain. 2024:awae068. doi: 10.1093/brain/awae068

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.