Vaccines Are Not Protecting Farmed Fish From Disease
The vaccines used by commercial fish farmers are not protecting fish from disease, according to a new study.
The study was compiled by researchers at the University of Waterloo, the Pontifical Catholic University of Valparaiso and Chile’s University of Valparaiso. It showed vaccinated fish tend to show more symptoms when contracting diseases, with the health impacts and ultimately deaths occurring as if they’d never received a vaccine.
“Today’s vaccines are marketed to fish farms as necessary disease prevention and are even required by some insurance companies, but they are not nearly as effective as needed under real world conditions.” said Brian Dixon, a professor in biology at Waterloo. “Some operators are giving five vaccinations per fish and then there are fish losses from the stress of receiving multiple handlings and injections.”
In the study, the researchers tested the efficacy of the vaccine for the bacterial pathogen Piscirickettsia salmonis by comparing the reaction of vaccinated and non-vaccinated Atlantic salmon when exposed to the sea louse Caligus rogercresseyi in the lab.
They found that although the number of bacteria living inside the fish was much lower in vaccinated fish, they showed many more signs of infection and a higher death rate compared with the unvaccinated group upon exposure to the sea lice.
The study concluded that once vaccinated, the salmon was unable to fight off multiple diseases at once. It’s first study showing how a parasite in fish can override the protective effects of a vaccine for another disease.
The experience of salmon farmers in Chile supports this finding, where salmon are raised largely in open cages off the coast, exposing them to variety of pathogens, the most common of which is sea lice.
The researchers say this highlights the need for veterinary pharmaceutical companies to change how they design and test vaccines in the first place, recognizing how different fish immune systems are from the current human model.
“Fish have a limited number of resources to respond to an illness so their immune system makes choices—when they’re infected by sea lice, for example, the fish’s immune system is suddenly geared to respond to that specific threat, leaving them totally exposed to other threats like P. salmonis,” said Dixon, a Canada Research Chair in Fish and Environmental Immunology. “It’s like sending ambulances out to all emergencies when in fact some of those emergencies need firefighters.”
In the 2008 Chile’s farmed salmon industry was nearly wiped out by Infectious Salmon Anaemia Virus (ISVA). Since then salmon farmers have been turning to vaccines to lower their use of antibiotics while prevent devastating losses from reoccurring disease. But vaccinations are expensive and can cost Chilean operators as much as 30 per cent of cost of raising each fish.
This article has been republished from materials provided by the University of Waterloo. Note: material may have been edited for length and content. For further information, please contact the cited source.
Carolina Figueroa, Paulina Bustos, Débora Torrealba, Brian Dixon, Carlos Soto, Pablo Conejeros, José A. Gallardo. Coinfection takes its toll: Sea lice override the protective effects of vaccination against a bacterial pathogen in Atlantic salmon. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-18180-6.
Human Malaria Parasites Grown for the First Time in Dormant FormNews
One of the biggest obstacles to eradicating malaria is a dormant form of the parasite which is resistant to most antimalarial drugs and can reawaken years later, causing disease relapse. Researchers have shown they can grow the dormant parasite in engineered human liver tissue for several weeks, allowing them to closely study how the parasite becomes dormant, what vulnerabilities it may have, and how it springs back to life.READ MORE
Innovative Nanomaterial Made From Natural SubstancesNews
Protein nanofibres often have outstanding properties such as a high stability, biodegradability, or antibacterial effect. Artificially creating these fibres is not easy, much less assigning them specific functions. That and how fibres with new properties can be successfully created is now being reported by materials scientists in a new study.READ MORE
Bacteria Produce More Substances Than Genetics PredictedNews
Tandem mass spectrometry has revealed that Streptomyces chartreusis, an antibiotic-producing bacterium, releases more metabolites into the surrounding medium than scientists assumed based on the analysis of the genome. They might include molecules that are of interest as potential pharmaceutical agents.READ MORE