When Microplastics Cross the Placenta, They Remain in Neonatal Tissue

Plastic pollution – tiny bits of plastic, smaller than a grain of sand – is everywhere, a fact of life that applies even to newborn rodents, according to a Rutgers Health study published in the journal Science of the Total Environment.

Researchers have long understood that micro- and nanoplastic particles (MNPs), which enter the environment through oxidation and natural degradation of consumer products, are easily deposited in the human body through inhalation, absorption and diet.

Experts also understand that these pollutants can cross the placental barrier and deposit in fetal tissues.

Nobody wants plastic in their liver. Now that we know it’s there – as well as in other organs – the next step is to understand why and what that means.

Phoebe A. Stapleton

Rutgers Ernest Mario School of Pharmacy

What’s been unclear is whether these particles remained in tissue long after birth. The Rutgers Health researchers found that they do, at least in rats. Their data that could have implications for human health.

“Nobody wants plastic in their liver,” said Phoebe A. Stapleton, an associate professor of pharmacology and toxicology at the Rutgers Ernest Mario School of Pharmacy, and the study’s senior author. “Now that we know it’s there – as well as in other organs – the next step is to understand why and what that means.”

To assess the persistence of micro- and nanoplastic particles in neonatal tissue following maternal exposure, Stapleton and colleagues exposed six rats to aerosolized food-grade plastic powder for 10 days during pregnancy.

Rodents are good test subjects for this type of study, Stapleton said, because humans and rodents both possess a hemochorial placenta, meaning that maternal and fetal blood don’t come into direct contact during circulation.

Two weeks after birth, two newborn rats – one male and one female – were tested for micro- and nanoplastic exposure. In both cases, the same type of plastic that the mothers inhaled during pregnancy were found in the offspring’s lung, liver, kidney, heart and brain tissue. No plastics were found in a control group.

Stapleton said the findings are one more piece of evidence illustrating the potential dangers of micro- and nanoplastics in the environment.

“These results raise concerns for the toxicological impacts associated with MNPs exposure, maternal-fetal health, and systemic MNPs particle deposition,” the researchers wrote.

Micro- and nanoplastics are a ubiquitous pollutant, and have been detected in food, farmland, seawater and snow. Plastics have even been found in the world’s deepest oceans and highest mountains.

These invisible pollutants are potentially hazardous to human health. An increasing body of evidence suggests a strong correlation between micro- and nanoplastic particles and cancer, inflammation, impaired immune function, tissue degeneration and cardiovascular problems.

Stapleton said she hopes her findings help create a sense of urgency among policymakers to make more funding available for research.

“Without answers we can’t have policy change,” she said.

Eventually, the persistence of these materials in human tissue could lead to greater regulation, Stapleton said. While plastics have undoubtedly improved consumer products, too little is known about their long-term health impacts. As researchers fill knowledge gaps, regulators will be better equipped to protect public health, she said.

“I don't think we'll ever get rid of plastics altogether,” she said. “They’re too important for modern life. But I do think we might get to a point where we’ll have some policies to indicate which ones are less toxic than others.”

Reference: Moreno GM, Brunson-Malone T, Adams S, et al. Identification of micro- and nanoplastic particles in postnatal sprague-dawley rat offspring after maternal inhalation exposure throughout gestation. Sci Total Environ. 2024;951:175350. doi: 10.1016/j.scitotenv.2024.175350

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

This content includes text that has been generated with the assistance of AI. Technology Networks' AI policy can be found here.