Whole Genome Sequencing for a Safer Food Supply
On April 11-12, the 40th Annual National Food Policy Conference was held in Washington, D.C. From a food safety perspective, the most inspiring moments came from the breakout panel titled, “Big Data and the Future of Food Safety.” The panel of industry experts discussed how government agencies and public health laboratories are working together to rapidly detect, investigate, and most importantly prevent foodborne outbreaks using a highly-accurate testing procedure called whole genome sequencing (WGS).
Using WGS, a pathogen’s complete DNA code can be uploaded from a food sample to an international, public database called GenomeTrakr, in a matter of minutes. The results are precise data sets that instantaneously link a specific strain of Listeria monocytogenes, for example, back to its original source. WGS has the capability to help us solve more outbreaks, link ill patients to likely food sources, and identify new food sources of Listeria, such as ice cream and caramel apples, by comparing information previously entered in GenomeTrakr with pathogens found in food and/or the environment.
Since 2013, the Food and Drug Administration (FDA) has collaborated with the National Center for Biotechnology Information (NCBI), Centers for Disease Control and Prevention (CDC), European Molecular Biological Laboratory (EMBL), the DNA Databank of Japan (DDBJ), and a network of public health laboratories to collect and store large amounts of genomic and geographical data about foodborne pathogens in GenomeTrakr. The goal for scientists around the world is to identify the complete DNA profile of each strain of pathogenic bacteria, virus and parasite present in foods, such as Listeria, Salmonella, E. coli, Campylobacter and Vibrio to combat foodborne illness.
As we collect more data about foodborne pathogens, we will gain a better understanding of how food becomes adulterated and how to identify the root cause of contamination. WGS’s straightforward, inexpensive and highly-accurate testing procedure is emerging as a gold standard for the future of food safety.
While this technology can provide rapid insight into foodborne pathogens, the entire food industry, from farm to fork, should remain committed to implementing the highest level of good manufacturing practices (GMPs) to prevent contamination.
Scientists have developed a way of amplifying DNA on a scale suitable for use in the emerging fields of DNA-based computing and molecular robotics. Their method could improve disease diagnostics and accelerate the development of biosensors, for example, for food and environmental applications.