Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS

Poster   Oct 11, 2013

 
Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS
 
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Fundamentals and Comparisons for Organic Sample Extract Evaporation

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Sample preparation is a key step in the analysis process

Parameters for evaporation and their impact on analysis have been discussed

Improvements in matching the sample to the evaporation device characteristics can help reduce variability and improve recovery

Examples for choosing a system based on sample volume, types of analytes, sample load, and initial investment considerations

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A New Method for Analyzing MSe/All Ions Fragmentation in Xenobiotic Metabolism Studies

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During early drug discovery, the study of metabolism plays an essential role in determining which drug candidates move forward into development and later stages. As an alternative to traditional Data Dependent Acquisition (DDA), the use of MSE/All Ions Fragmentation (AIF) has become common in metabolite identification workflows for the analysis of metabolic hot spots. Here we present a solution for analysis of MSE/AlF in metID studies.

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Using Elemental Analysis For Discrimination Of Pinot Noir Wines From Six Different Districts In An Ava

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The determination of geographical origin of wine is gaining increased interest by researchers and federal agencies around the world, partially due to increased fraud with regards to place of origin labelling. For wine, multi-elemental profiling of macro, micro, and trace elements has been proposed for determination of authenticity. Commercial wines from different wineries in 5 different neighborhoods within one AVA show characteristic elemental fingerprints. Macro, micro and trace elements as well as elemental ratios contribute to the observed separation, indicating the involvement of multiple factors and underlying mechanisms, including location and soil composition, elemental uptake by vine and rootstock, viticulture and nutrient management, water sources, and small differences in the different wineries.

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