High Throughput Screening with Infectious Agents: Equipment Choices and Strategies
Poster May 03, 2007
Nicole L. Kushner, William Severson, Jim Noah, Nice Shindo, Lynn Rasmussen, Colleen Jonsson and E. Lucile White.
At Southern Research Institute we routinely conduct HTS campaigns using infectious agents at the BSL-2 (Biosafety Level) and BSL-3 level. Here we discuss how we have successfully screened over one million compounds in anti-viral (Severe Acute Respiratory Syndrome, Influenza, Highly Pathogenic Avian Influenza) and anti-microbial (Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis) screens in BSL-2 and BSL-3 containment.