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High Throughput Screening with Infectious Agents: Equipment Choices and Strategies

At Southern Research Institute we routinely conduct HTS campaigns using infectious agents at the BSL-2 (Biosafety Level) and BSL-3 level. Here we discuss how we have successfully screened over one million compounds in anti-viral (Severe Acute Respiratory Syndrome, Influenza, Highly Pathogenic Avian Influenza) and anti-microbial (Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis) screens in BSL-2 and BSL-3 containment.