Isothermal Titration Microcalorimetry: An Essential Tool for Fragment-Based Drug Discovery
Poster Mar 05, 2021
Concept Life Sciences, Malvern Panalytical
Isothermal titration microcalorimetry (ITC) is an essential tool in drug discovery, enabling researchers to study and regulate protein interactions. Recent advancements in ITC instrumentation have led to an increase in the throughput and decrease in the protein consumption of the technique. When combined with the extended affinity range, these factors make the technique ideal for fragment-based drug discovery campaigns.
Download this poster to discover how ITC:
The changing landscape for antibody-derived therapeutics, such as bi-specific monoclonal antibodies, Fab fragments and Fc-fusion proteins brings new purification challenges in the downstream processing of these molecules. Standard chromatography resins, such as Protein A, may not result in the most efficient purification process.READ MORE