TMT Quantification for Shotgun Proteomics: TIMS-QTOF Powered by PASEF
Poster May 31, 2019
Matt Willetts, Shourjo Ghose, Heiner Koch, Scarlet Koch, Markus Lubeck, Gary Kruppa.
This poster evaluates the performance of ‘timsTOF Pro’ a unique dual trapped ion mobility spectrometer (TIMS) coupled to a QTOF for the analysis of isobaric labelling experiments.
Download to discover:
- How TIMS provides an additional dimension of separation and high peak capacity
- Why the timsTOF Pro instrument is well suited to isobaric labelled quantitation experiments
- How to achieve near 100% duty cycle for shotgun proteomics
The changing landscape for antibody-derived therapeutics, such as bi-specific monoclonal antibodies, Fab fragments and Fc-fusion proteins brings new purification challenges in the downstream processing of these molecules. Standard chromatography resins, such as Protein A, may not result in the most efficient purification process.READ MORE
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