Nanoscale 1D-LC Peptide Separation System from GE Healthcare

GE Healthcare has announced the introduction of Ettan™ nanoLC, a fully bio-inert nanoscale peptide separation system that is designed to delivers reproducible performance and is ideal for 1D-liquid chromatography proteomics applications upstream from electrospray ionization mass spectrometry or MALDI MS/MS applications.
 
The nanoLC extends the range of applications of GE Healthcare's family of Ettan chromatography systems, which includes Ettan LC system, Ettan microLC, and Ettan MDLC multidimensional liquid chromatography system.

The nano LC is suited for those with limited funding requiring a 1DLC system who don't want to compromise on sensitivity enabled by our LC platform.

The Ettan nano LC performs high-pressure gradient formation with unmatched reproducibility and online, real-time gradient monitoring, while maintaining a continuous flow to the ion source or MALDI spotter throughout a run.

The instrument's low dead volumes ensure minimum peak broadening and consistent peak concentrations for maximum sensitivity and resolution.

"The Ettan nanoLC platform includes the high quality components GE Healthcare customers have come to value in our AKTA™ chromatography systems," says Jasmine Gruia-Gray, global marketing director, Protein Discovery at GE Healthcare.

"The bio-inert system offers unique advantages for peptide separation of labile phosphopeptides upstream from electrospray ionization MS."

Integrated system components include a flow splitter that is designed to ensure gradient elution at flow rates as low as 200 nl/min, UV and conductivity monitors, the P-905 pump, a pressure sensor, and biocompatible flow path and pump heads.

The Peltier-cooled Autosampler A-905 allows injection of as little as 100 nl of sample from vials or microtiter plates.

Control and evaluation of the chromatographic process can be achieved using GE Healthcare's UNICORN™ software or via a virtual interface with the MS software module.