Thermo Fisher Scientific Expands Orbitrap Mass Spectrometry Portfolio

Thermo Fisher Scientific has expanded its suite of Thermo Scientific^TM Orbitrap^TM mass spectrometry platforms, AI-enabled software and integrated workflows at the American Society for Mass Spectrometry (ASMS) Conference.

Across research, biopharma and applied testing, scientists face increasingly complex samples, expanding data sets and greater pressure to deliver confident answers faster. Thermo Fisher helps solve that challenge by bringing its flagship Orbitrap technology to more scientific decision points. The company’s expanded portfolio combines the depth of high-resolution accurate-mass technology with end-to-end solutions, enabling laboratories to advance discoveries, accelerate the development of new medicines and ensure more confident testing for food, air and water.

“Orbitrap technology has long set the standard for breakthrough discovery, and customers now want that same confidence across applied scientific markets,” said Ronald Tabaksblat, president, chromatography and mass spectrometry, Thermo Fisher Scientific. “At ASMS 2026, we are showcasing how Thermo Fisher is scaling Orbitrap innovation through connected platforms, software and workflows that support advanced research, drug development and applied testing with decision-ready results.”

Clearer Disease Insights in Research

The new Thermo Scientific Orbitrap Tribrid^TM Apex Mass Spectrometer (MS) gives researchers a more powerful way to study challenging samples on a single platform. As Thermo Fisher’s most versatile and highest-performing Orbitrap Tribrid, the Orbitrap Tribrid Apex MS brings multiple capabilities together in one system, including three mass analyzers, a new infrared laser option for alternative fragmentation and Thermo Scientific Direct Mass Technology^TM Mode. Together, these features help researchers get clearer answers from complex biology earlier in the discovery process. Thermo Fisher also expanded its software capabilities across proteomics, spectral analysis and advanced protein characterization: 

•  MSAID and Proteinaceous, Thermo Fisher’s recent software acquisitions, deliver smarter proteomics workflows that speed analysis and streamline connectivity. MSAID brings AI-driven proteomics and machine learning expertise, while Proteinaceous adds top-down and native mass spectrometry bioinformatics.
• Thermo Scientific Proteoform Studio Software provides researchers with a streamlined proteomics workflow from acquisition through reporting, including Direct Mass Technology analysis for deeper characterization.
• Thermo Scientific Proteome Discoverer^TM 3.4 Software helps scientists manage more proteomics workflows in one place, making it easier to analyze additional data with greater flexibility, speed and coverage.

Greater Confidence in Biopharma and Pharma Drug Development

Thermo Fisher unveiled the Thermo Scientific Orbitrap Excedion^TM Mass Spectrometer an Orbitrap platform designed to reduce performance tradeoffs in drug development. Built for applications ranging from drug metabolism studies to oligonucleotide and peptide analysis, the Orbitrap Excedion MS offers enhanced dynamic range (eDR) that detects three to five times more compounds in complex samples and delivers more reproducible results across larger studies. For the first time, laboratories can upgrade to Orbitrap Excedion Pro MS without replacing their instrument, which expands their analytical power while minimizing cost and disruption to ongoing work.

Thermo Fisher also introduced complementary innovations that provide biopharmaceutical development labs with a ready-made, end-to-end workflow:

• Thermo Scientific Vanquish^TM Amplify UHPLC Systems use an inert, metal-free sample flow path engineered to minimize adsorption and secondary interactions, helping scientists analyze sensitive biological molecules, such as short oligos, with less sample loss, better reproducibility and greater confidence in results from method development through QC.
• Thermo Scientific SurePac^TM RP MDi^TM Columns are purpose-built for oligonucleotide, mRNA and protein therapeutic analysis, helping improve recovery, separation and reproducibility under demanding conditions.
• Thermo Scientific SMART Digest^TM OligoSelect^TM Kit simplifies sample preparation for oligonucleotide bioanalysis with a single, streamlined workflow that reduces time and cost.
• Thermo Scientific BioPharma Finder^TM 5.5 Software helps scientists process complex top-down mass spectrometry data from the latest Thermo Fisher instruments faster while maintaining consistent results.

As drugs move further through development, laboratories need robust workflows for regulated bioanalysis and QA/QC. For these later-stage needs, Thermo Fisher will also showcase the Thermo Scientific TSQ Certis^TM Triple Quadrupole Mass Spectrometer. It helps scientists accelerate drug development by measuring samples 15% faster and running more than twice as long between maintenance events for complex matrices like plasma.

Regulatory-ready Results for Food and Environmental Safety

The Thermo Scientific Orbitrap Exploris^TM GC S Mass Spectrometer is a high-resolution gas chromatography-mass spectrometry platform designed to modernize dioxin and persistent organic pollutants (POPs) analysis for environmental and food safety laboratories. As regulations evolve and contaminant lists expand, the Orbitrap Exploris GC S MS delivers regulatory-ready, ultra-trace results with the sensitivity and resolving power needed for confident, reliable testing. With more than twice the resolution of many existing systems, it also helps laboratories identify emerging contaminants without additional instruments, saving time and reducing complexity in high-stakes public health or environmental testing.

Thermo Fisher will also showcase the Thermo Scientific Orbitrap Exploris EFOX Mass Detector for high-resolution screening of PFAS, pesticides and related contaminants, alongside the Thermo Scientific TSQ Altis^TM Plus EFOX Triple Quadrupole Mass Spectrometer for reliable, high-throughput quantitation. Together with application expertise and service, these systems help environmental, water and food safety laboratories detect known and emerging contaminants faster, respond to potential risks sooner and make more confident public health decisions.

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