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Cancer Genetics – Multimedia

A Multiplexed Amplicon Sequencing Technology for FFPE and Circulating, Cell-free DNA content piece image
Poster

A Multiplexed Amplicon Sequencing Technology for FFPE and Circulating, Cell-free DNA

A novel amplicon approach allowing for hundreds of amplicons to be multiplexed in a single tube with a two workflow from sample to sequencer.
Trace Level Analysis of Perchlorate and Bromate in Various Water Matrices using Suppressed Ion Chromatography content piece image
Poster

Trace Level Analysis of Perchlorate and Bromate in Various Water Matrices using Suppressed Ion Chromatography

Bromate and Perchlorate are ubiquitous analytes in various water matrices and analysis in trace level is a challenge
Lab-on-a-Chip System for Detection of Mycotoxins in Animal Feed content piece image
Poster

Lab-on-a-Chip System for Detection of Mycotoxins in Animal Feed

This poster introduces an automated Lab-on-a-Chip system for reliable quantitative testing of mycotoxin contamination of animal feed developed in the framework of the EU-funded project micro- FLUID.
An In Silico Test Battery for Rapid Evaluation of Genotoxic and Carcinogenic Potential of Chemicals content piece image
Poster

An In Silico Test Battery for Rapid Evaluation of Genotoxic and Carcinogenic Potential of Chemicals

The FDA guidance for industry states impurities under the ICH threshold may be exaluated for genotoxicity and carcinogenicity. This study uses an expert system to detect mutagens and compounds labeled as potent carcinogens by the FDA.
Demethylation and Re-Expression of Tumor Suppressor Genes: A Novel Approach for Cancer Therapy content piece image
Poster

Demethylation and Re-Expression of Tumor Suppressor Genes: A Novel Approach for Cancer Therapy

In this study, we demonstrated that a combination therapy using suboptimal doses of HDACi and calpeptin, an inhibitor of calpain, produced synergistic type growth inhibition and reduced cancer cell motility in cancer cells. We hypothesize that the re-expression of tumor suppressor genes by demethylation and other mechanisms sensitize the cells and allows for apoptotic death.
New Approach for In Silico Genotoxicity Testing of Impurities and Degradants content piece image
Poster

New Approach for In Silico Genotoxicity Testing of Impurities and Degradants

This study presents a novel approach to aid this assessment based on probabilistic predictors of mutagenicity in Ames test and binding to Estrogen Receptor, supplemented by a knowledge-based system of structural alerts.
Quantitative phosphoproteome analysis for the detection of early alterations of signal transduction by dioxin (TCDD) content piece image
Poster

Quantitative phosphoproteome analysis for the detection of early alterations of signal transduction by dioxin (TCDD)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an extremely toxic pollutant and regarded the most potent chemical carcinogen in experimental animals. Most of its biological effects are mediated by binding of TCDD to the cytosolic Ah receptor (AHR). In addition, TCDD cause AHR-dependent alterations in signal transduction that are independent of changes in gene expression. In this study, we have therefore conducted a quantitative phospho proteomic study on TCDD-induced alterations.
Co-rgulation of tumour suppressor gene programmed cell death 4 (PDCD4) by miR-21 and miR-499 in head and neck cancer content piece image
Poster

Co-rgulation of tumour suppressor gene programmed cell death 4 (PDCD4) by miR-21 and miR-499 in head and neck cancer

This study has identified differentially expressed miRNAs in tonsil cancers and provides new evidence for co-regulation of the oncogene PDCD4 by miR021 and miR-499
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