Cancer Genetics – News and Features

Research reveals that higher concentrations of extrachromosomal DNA (ecDNA) in aggressive tumors may aid cancer survival, marking it as a potential target for therapies. The study found ecDNA more prevalent in previously treated patients.

In a new study, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses.

Researchers have established the English National Lynch Syndrome Registry, the UK’s first comprehensive database for patients with Lynch syndrome. This initiative links genomic data with cancer diagnosis and treatment information.

Researchers have discovered that combining immunotherapy and chemotherapy can overcome treatment resistance in a subset of lung cancer patients.

Researchers found that specific genetic mutations in Black patients with acute myeloid leukemia (AML) significantly affect survival outcomes. Their findings stress the importance of including ancestry-specific factors in AML risk stratification.

Researchers have discovered that a novel combination therapy promotes cancer cell death and tumor regression in pancreatic cancer.

Researchers have discovered that the prevalent cytosine-to-thymine mutations in cancer are mainly due to mistakes in DNA replication rather than spontaneous reactions. The study identifies the role of the DNA-copying enzyme.

A new clinical testing pathway could identify cancer-causing BRCA mutations, ensuring patients get the right treatment.

Researchers at Baylor College of Medicine and collaborating institutions have discovered a mechanism that drives the long-term decline in immune response that is observed after tuberculosis (TB) has been successfully treated.

Researchers at Weill Cornell Medicine developed a CRISPR-based mouse model to track prostate cancer metastasis. By using genetic barcoding, they mapped the spread of cancer cells and identified patterns that mirror human cancer behavior.