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Cancer Immunology – News and Features

Cancer cells.
News

Novel Cancer Therapy Activates Only Near Tumors, Reducing Side Effects

Researchers at UC San Francisco developed SNIPRs, sensors that activate engineered cells only in the tumor environment, offering targeted cancer treatment. When tested in mice, the SNIPR-equipped cells attacked only tumor cells.
Cell therapy.
News

CAR T-Cell Therapy Fights Lethal Childhood Brain Cancer in Trial

A Stanford Medicine trial has shown success with CAR-T cell therapy in shrinking deadly childhood brain tumors. For one patient, tumor traces disappeared completely, marking a promising development in treating diffuse intrinsic pontine glioma (DIPG).
Cancer cells.
News

CAR T-Cell Therapy Attacks Brain Tumors From Multiple Angles

Researchers at the University of Basel have developed CAR T-cells that target glioblastoma, a notoriously aggressive brain cancer. This approach not only attacks tumor cells directly but also neutralizes the tumor’s supportive microenvironment.
Two images, one showing how immune organ-on-a-chips are grown, the other a close-up of immune cell development in an organoid.
News

Lab-Grown Model Reveals Weakened Immune Response in Cancer Patients

Tiny lab-grown models of human immune systems are helping researchers understand why cancer patients struggle to fight infections.
Antibodies.
News

Antibody Developed With Potential To Treat Several Types of Cancer

Researchers developed a 3-in-1 antibody that targets tumors, delivers treatment, and activates immune cells to enhance T-cell response. The customizable, scalable method shows potential for safer and quicker precision cancer therapy.
Immunotherapy molecules fighting a cancer cell.
News

Virtual Drug Screening Identifies Candidates for Cancer Immunotherapy

Researchers at Weill Cornell used virtual screening to find small molecules targeting cancer checkpoints, showing promise as alternatives to monoclonal antibody treatments. The study identified compounds MG-T-19 and MG-V-53.
A cancer cell highlighted in orange with a target focussed on it.
News

Cancer-Killing Virus Shows Promise Against Aggressive Brain Tumors

Researchers have engineered an adenovirus to selectively target and kill aggressive brain cancer cells, which has shown promise in a phase 1, dose-escalation study.
Cancer cells.
News

A New Target for Colorectal Cancer Treatment

USC researchers have found that targeting CD47, a protein enabling cancer to evade immune cells, could enhance colorectal cancer treatments. Blocking CD47, combined with traditional therapies, could stimulate immune responses against tumors.
Two brain scans of a patient with glioblastoma, in one the mass is small and contained, and in the other it has spread.
News

Drug Combination Flags Brain Tumor Cells for Immune System Attack

In a cell-based study, researchers have forced glioblastoma cells to display immune system targets, making them visible to the immune system and vulnerable to immunotherapies.
Antibodies.
News

AI Tool Identifies Better Antibody Therapies

Georgia Tech researchers created AF2Complex, a deep-learning tool that predicts antibody interactions with proteins, enhancing immunotherapy development. The model accurately identified effective antibodies against Covid-19.
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