Cancer Immunology – News and Features

A study from Van Andel Institute reveals that immune cells use two pathways, ACLY and ACSS2, to produce acetyl-CoA, an essential metabolite for fighting infection and cancer. These findings highlight the interplay between metabolism and epigenetics.

University of Queensland research could lead to a more effective immunotherapy treatment against bladder cancer. A team has found the mechanism used by bladder cancer to suppress the immune system’s natural killer (NK) cells.

A light-controlled "appetizer" that stimulates macrophages can increase their appetite for cancer cells, finds a new study.

Florida State University researchers are giving oncologists another tool in their fight against pediatric brain cancer. Researchers showed the possibility of enhancing natural killer immune cells to improve their ability to attack.

This may come as a surprise, but the BCG vaccine against tuberculosis is the oldest immunotherapy against cancer. Now, a team from the Champalimaud Foundation, in Lisbon, has found the first steps of its action to destroy cancer cells.

Scientists have taken a fresh approach to finding a way to target neuroblastoma, the most common solid tumor of infancy. Their novel gene target could offer hope for finding alternative treatments with fewer long-term side effects.

Immunobiologists found that a subset of immune cells that normally puts the brakes on the immune system to prevent it from attacking the body’s healthy cells inadvertently also dampens cancer immunotherapy.

Meteorin-like (METRNL) protein saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research. Blocking METRNL signaling may allow immune cells to regain the energy necessary to eliminate tumors.

A team of research groups discovered that a migration path used by cells during brain development can be hijacked for cancer cell invasion, opening up new opportunities for treating aggressive brain cancers like glioblastoma.

A new technique to help CAR T-cells persist longer in the body and form a memory of the cancer cell could prevent cancer recurrence.