Cancer Immunology – News and Features

Researchers revealed that checkpoint inhibitors, a powerful cancer immunotherapy, impair B cell function, reducing antibody diversity and increasing infection risk. They suggest immunoglobulin replacement therapy as a preventive measure.

Researchers at the University of Freiburg discovered that mitochondria regulate the balance between cell death and inflammation. A sudden ATP drop prevents apoptosis and activates NLRP3-mediated inflammation.

This article explores the difficulties faced in attempting to treat HIV, an innovative prevention strategy and the possibility of a cure.

Researchers explore how established agricultural pest management strategies could be adapted to address cancer therapy. The pioneering method opens new possibilities for controlling drug resistance and improving patient survival.

Researchers have revealed how IDH mutations in gliomas act as a "ticking time bomb," initiating slow growth before genetic mutations drive aggressive cancer progression. The study highlights epigenetic immune suppression and cellular shifts.

RNA therapeutics promise rapid, personalized and flexible treatments against multiple diseases. In this article, we will explore whether RNA therapeutics can realize their full potential.

New research provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment.

T-cell dysfunction linked to obesity prevents T cells from detecting tumor cells, increasing cancer risk.

A novel CAR-T therapy targeting p95HER2 shows complete and durable tumor responses in HER2+ breast cancer preclinical models. Combining CAR-T cells with a bispecific antibody, this approach enhances immune activation while avoiding toxicities.

Researchers at UC San Francisco developed SNIPRs, sensors that activate engineered cells only in the tumor environment, offering targeted cancer treatment. When tested in mice, the SNIPR-equipped cells attacked only tumor cells.