Cancer Immunology – News and Features

News
Enzyme May Be Therapeutic Target Against “Cold” Tumors
University of Michigan researchers identified UBA1 as a key player in immunotherapy resistance. Inhibiting UBA1 boosts T-cell recruitment, converting cold tumors to hot, and enhancing the effectiveness of immune checkpoint blockade therapies.

News
Novel Immunotherapy for Brain Cancer Designed
Researchers have designed a novel immunotherapy, based on a tri-specific antibody, for glioblastoma, the deadliest form of brain cancer.

News
Updated CRISPR Toolkit Enables Remote-Controlled Genome Editing
Focused ultrasound can allow CRISPR gene editing to be precisely targeted and controlled remotely.

News
High Response Rate for CAR T-Cell Therapy in Patients With Fast-Growing Leukemia
A novel CAR T-cell therapy has benefitted patients with relapsed acute lymphoblastic leukemia, showing high response rates in a Phase Ib/II trial.

News
Mechanisms That Make Ewing Sarcoma More Aggressive Discovered
A study from Spain’s CNIO identifies genetic alterations linked to STAG2 loss, driving aggressiveness in Ewing sarcoma. These changes increase metastasis and impact immune response, offering new prognostic markers and therapeutic targets.

News
Cancer Researchers Think They Now Know Why Immune Checkpoint Inhibitor Therapies Increase Infection Risk
Researchers revealed that checkpoint inhibitors, a powerful cancer immunotherapy, impair B cell function, reducing antibody diversity and increasing infection risk. They suggest immunoglobulin replacement therapy as a preventive measure.

News
Mitochondria Not Only Fuel Cells They Also Influence Inflammation
Researchers at the University of Freiburg discovered that mitochondria regulate the balance between cell death and inflammation. A sudden ATP drop prevents apoptosis and activates NLRP3-mediated inflammation.

Article
Unveiling the Progress and Challenges in the Fight Against HIV
This article explores the difficulties faced in attempting to treat HIV, an innovative prevention strategy and the possibility of a cure.

News
What Can Cancer Research Learn From Agricultural Pest Management?
Researchers explore how established agricultural pest management strategies could be adapted to address cancer therapy. The pioneering method opens new possibilities for controlling drug resistance and improving patient survival.

News
Source of Brain Cancer’s Deadly Transformation Identified
Researchers have revealed how IDH mutations in gliomas act as a "ticking time bomb," initiating slow growth before genetic mutations drive aggressive cancer progression. The study highlights epigenetic immune suppression and cellular shifts.
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