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Cancer Immunology – News and Features

Cancer cells.
News

Enzyme May Be Therapeutic Target Against “Cold” Tumors

University of Michigan researchers identified UBA1 as a key player in immunotherapy resistance. Inhibiting UBA1 boosts T-cell recruitment, converting cold tumors to hot, and enhancing the effectiveness of immune checkpoint blockade therapies.
Two red immune cells attack a white cancer cell.
News

Novel Immunotherapy for Brain Cancer Designed

Researchers have designed a novel immunotherapy, based on a tri-specific antibody, for glioblastoma, the deadliest form of brain cancer.
A blue and pink strand of DNA, with one piece being removed.
News

Updated CRISPR Toolkit Enables Remote-Controlled Genome Editing

Focused ultrasound can allow CRISPR gene editing to be precisely targeted and controlled remotely.
A cancer cell being attacked by immune cells.
News

High Response Rate for CAR T-Cell Therapy in Patients With Fast-Growing Leukemia

A novel CAR T-cell therapy has benefitted patients with relapsed acute lymphoblastic leukemia, showing high response rates in a Phase Ib/II trial.
Cancer cells.
News

Mechanisms That Make Ewing Sarcoma More Aggressive Discovered

A study from Spain’s CNIO identifies genetic alterations linked to STAG2 loss, driving aggressiveness in Ewing sarcoma. These changes increase metastasis and impact immune response, offering new prognostic markers and therapeutic targets.
Immunotherapy molecules attacking a cancer cells.
News

Cancer Researchers Think They Now Know Why Immune Checkpoint Inhibitor Therapies Increase Infection Risk

Researchers revealed that checkpoint inhibitors, a powerful cancer immunotherapy, impair B cell function, reducing antibody diversity and increasing infection risk. They suggest immunoglobulin replacement therapy as a preventive measure.
A mitochondria in neon lights.
News

Mitochondria Not Only Fuel Cells They Also Influence Inflammation

Researchers at the University of Freiburg discovered that mitochondria regulate the balance between cell death and inflammation. A sudden ATP drop prevents apoptosis and activates NLRP3-mediated inflammation.
A red beaded ribbon-shape resting in cupped hands.
Article

Unveiling the Progress and Challenges in the Fight Against HIV

This article explores the difficulties faced in attempting to treat HIV, an innovative prevention strategy and the possibility of a cure.
3D visualization of cancerous cells showing a dense cluster of irregular blue and pink spheres.
News

What Can Cancer Research Learn From Agricultural Pest Management?

Researchers explore how established agricultural pest management strategies could be adapted to address cancer therapy. The pioneering method opens new possibilities for controlling drug resistance and improving patient survival.
Cancer cells.
News

Source of Brain Cancer’s Deadly Transformation Identified

Researchers have revealed how IDH mutations in gliomas act as a "ticking time bomb," initiating slow growth before genetic mutations drive aggressive cancer progression. The study highlights epigenetic immune suppression and cellular shifts.
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