CRISPR and Genome Editing – Multimedia

In this list we look at 6 promising ultra-low cost diagnostic technologies, which could help take the tools to where they are most needed.

Think it’s scary that geneticists are altering the genetic code of animals to make them glow in the dark? Then you’ll love knowing that you’ve probably been ingesting and cohabitating with genetically modified plants without even knowing it.

We aim to better understand the parameters affecting CRISPR-Cas9 editing efficiency for functional gene knockout utilized synthetic crRNAs and tracrRNA.

Because of the possible beneficial role of polyamines, metabolism of arginine by arginase is of interest. Recently, our lab has recently shown that arginase1 overexpression has the ability to reduce phosphorylated tau and neurofibrillary tangles in rTg4510 and PS19 tau transgenic mice. Based on these data, we utilized the transgenic tetO MAPT*P301L mouse model to examine a potential therapeutic gene of interest, arginase1, in an animal model of tauopathy.

Salk scientists advance stem-cell and genome-editing technologies to help researchers study evolution and disease, test therapeutic drugs and possibly grow transplantable organs.

Our results indicate that MS modifications are required for experiments with co-electroporation of Cas9 mRNA and synthetic gRNA, yet have no impact on editing efficiency when delivered with lipid-based transfection reagents.

AstraZeneca present data, showing large scale generation of functional pancreatic beta-cells, at a scale commensurate with drug-discovery activities. Furthermore, data is presented demonstrating the power of combining precise genome editing with iPSC technology in target validation.

Here we take a look at 5 films that get biology very wrong.

The aim of this study is to understand the mechanism behind the association between single nucleotide polymorphisms (SNPs), lying in non-coding regions near or within RAD51B and RAD23B, and prostate cancer risk by analysing their interactions with the whole genome using Circular Chromosome Conformation Capture (4C).

This webinar presents a comparison of loss-of-function genetic screens performed with CRISPR versus RNAi technology.