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High-Throughput Screening – Multimedia

NanoBRET™ Assays for Monitoring Protein Interactions in Living Cells content piece image
Poster

NanoBRET™ Assays for Monitoring Protein Interactions in Living Cells

Learn how NanoBRET assays can be used to interrogate protein events such as epigenetic interactions, adaptor recruitment to membrane receptors and proteasomal recruitment of proteins targeted for degradation.
Using Cells as Models content piece image
Video

Using Cells as Models

Mark Wigglesworth PhD, Director of High Throughput Screening at AstraZeneca tells us how using cells as models is improving the success of drug discovery.
Optogenetics on FDSS7000EX: Light-stimulated membrane depolarization in cultured cells expressing channelrhodopsin using a kinetic plate reader content piece image
Poster

Optogenetics on FDSS7000EX: Light-stimulated membrane depolarization in cultured cells expressing channelrhodopsin using a kinetic plate reader

The aim of this study was to establish clonal cell lines stably expressing a channelrhodopsin variant and measure membrane potential changes with a fluorescent dye induced by repetitive light-stimulations in a 96-well plate on a kinetic plate reader FDSS 7000EX.
Novel Biosensor Technologies for Detection and High Throughput Screening of Pathogens and Toxins content piece image
Video

Novel Biosensor Technologies for Detection and High Throughput Screening of Pathogens and Toxins

Arun Bhunia's research team is currently developing high throughput nano/biosensor-based screening tools such as the fiber optic, cell-based and light scattering for detection of multi-pathogens and toxins from food.
Mass Spectrometry and High-Throughput Screening content piece image
Video

Mass Spectrometry and High-Throughput Screening

Jonathan Wingfield, principal scientist at AstraZeneca, talks about the AstraZeneca Open Innovation Portal and the use of acoustic mass spectrometry for high-throughput screening.
The Need for Speed content piece image
Infographic

The Need for Speed

Evaluating MALDI-TOF as a high-throughput screening technology for the pharmaceutical industry.
Choosing & Using Fragments in the Generation of Selective Kinase Inhibitors content piece image
Video

Choosing & Using Fragments in the Generation of Selective Kinase Inhibitors

Development of a Homogenous RSV Neutralization Assay on the Mirrorball Fluorescence Cytometer: A Simple, Safe and Robust Approach for High-throughput Screening content piece image
Poster

Development of a Homogenous RSV Neutralization Assay on the Mirrorball Fluorescence Cytometer: A Simple, Safe and Robust Approach for High-throughput Screening

Here we present the development and implementation of a simple RSV-neutralization assay on TTP Labtech’s mirrorball fluorescence cytometer.
A Novel Bioluminescent HTS Method for Rapid NAD(P)/NAD(P)H Detection Poster content piece image
Poster

A Novel Bioluminescent HTS Method for Rapid NAD(P)/NAD(P)H Detection Poster

Nicotinamide adenine dinucleotides (NAD+, NADH, NADP+ and NADPH) are fundamental co-factors of cellular energy metabolism. These dinucleotides are essential for macromolecule biosynthesis and the maintenance of the cellular redox potential. Our new rapid, easy-to-use assays for measuring dinucleotides are convenient tool for investigating their role in these processes.
A New Dual Luciferase Assay Using NanoLuc® Enables a Second Generation Coincidence Reporter System to Reduce False Hits in HTS Poster content piece image
Poster

A New Dual Luciferase Assay Using NanoLuc® Enables a Second Generation Coincidence Reporter System to Reduce False Hits in HTS Poster

Luciferase-based reporter-gene assays remain a cornerstone of high-throughput screening of compounds because of their high sensitivity and dynamic range. However, a substantial number of non-relevant hits can be generated due to direct interaction of compounds with the luciferase reporter.
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