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High-Throughput Screening – Multimedia

An HTS-Compatible Plate For Highly Miniaturized Cultures Of Primary Human Bronchial Epithelial Cells At Air-Liquid Interface content piece image
Poster

An HTS-Compatible Plate For Highly Miniaturized Cultures Of Primary Human Bronchial Epithelial Cells At Air-Liquid Interface

Primary human bronchial epithelial cells (HBE) cultured at air liquid interface (ALI) exhibit striking similarity to the in vivo situation, including both tissue architecture and ion channel functionality. Cultures of this type serve as a gold standard for predicting therapeutic activity in airway diseases such as cystic fibrosis.
Video

From Batch to Continuous Flow Processing: Development of Safe and Improved Methods for Aerobic Oxidation

Alain Favre-Reguillon, University of Lyon, speaking at Flow Chemistry India 2015
Video

High-Throughput Approaches to Cell Biology

Robin Ketteler, University College London, discusses high throughput screening of autophagy using siRNA and small molecule compounds.
Video

Choosing & Using Fragments in the Generation of Selective Kinase Inhibitors

There is often a debate about just how useful fragments are for well-established conventional targets such as protein kinases. Fragment screening however can be extremely valuable, providing critical ideas that lead to novelty, demonstrating how to achieve selectivity, helping dissect and make the most of HTS and literature compounds, alongside maximising ligand efficiency.
Alzheimer's Disease Model Cells Derived from Human iPS Cells content piece image
Poster

Alzheimer's Disease Model Cells Derived from Human iPS Cells

Alzheimer's disease model neurons were created from iPS cells to enable functional, cell-based assays for AD.
Phenotypic Screening Applied to the Anti-biofilm Drug Discovery: Identification of Anti-biofilm Flavonoids from a Chemical Library content piece image
Poster

Phenotypic Screening Applied to the Anti-biofilm Drug Discovery: Identification of Anti-biofilm Flavonoids from a Chemical Library

This work represents a systematic exploration of a flavonoids collection for the inhibitory activity against Staphylococcus aureus biofilms and offers an improved methodological workflow for anti-biofilm screens of chemical libraries taking into account the connections between anti-biofilm and antibacterial properties.
EU-OPENSCREEN - The European Research Infrastructure of Open Screening Platforms for Chemical Biology content piece image
Poster

EU-OPENSCREEN - The European Research Infrastructure of Open Screening Platforms for Chemical Biology

EU-OPENSCREEN (www.eu-openscreen.eu) is the largest emerging academic chemical biology research infrastructure initiative in Europe with the aim to collaboratively develop novel research tool compounds with external scientists. As a joint effort of national networks in 16 European countries, EU-OPENSCREEN offers access to high-throughput screening platforms, chemistry services, an open-access database, a large compound collection and an open-access database.
App Note / Case Study

The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability

This experiment demonstrates that thermal and colloidal stability of proteins, two indicators of propensity to aggregate, as well as actual aggregation states, are all determined simultaneously during the screening process with dynamic light scattering (DLS) tools in order to rank the effectiveness of candidates and formulation conditions.
Pressure-Based Volume Measurement Technology for In-process Measurement of Microplate Contents content piece image
Poster

Pressure-Based Volume Measurement Technology for In-process Measurement of Microplate Contents

Modern drug discovery and research labs are utilizing complex automation systems to assist in
high throughput screening of novel drug candidates. A large portion of these laboratories are
using ANSI-SBS-standard 96- and 384-well plates to achieve the necessary throughput. The volume
of sample transferred into and out of these plates can be critical to the success of assays or
validation of procedures.
Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method content piece image
Poster

Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method

This study demonstrates that the cell culture assay for tumorsphere size was successfully adapted to 384-well plate for a 3D spheroid assay using U-bottom low attachment 384-well and the Celigo Automated Imager for image acquisition and analysis. Moreover, the utilization of an imager provided insight on sphere and cell fate after long term drug treatment.
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