High-Throughput Screening – News and Features

Structure verification by NMR is a vital task in drug discovery but can be slow and subjective. This article explores how ASV transforms it into a scalable, consistent and reliable process.

To be able to study ALS-linked neuroinflammation in the lab, researchers generated “spinal microtissues” containing motor neurons and immune cells from ALS patients' stem cells.

Researchers have identified several uncharacterized chromatin factors and a gene that are involved in DNA repair.

Researchers have identified a small molecule that can selectively block cell death. The findings lay the groundwork for next-generation neuroprotective drugs for degenerative conditions, which currently have no cure or treatments.

Phenotypic screening has re-emerged as a powerful strategy for identifying drugs based on their observable effects. Discover how phenotypic screening accelerates drug discovery, supports drug repurposing and enables novel therapeutic breakthroughs.

Scientists have designed new drug frameworks that selectively target CYP3A4, one of the most critical CYP proteins. Structural insights from this work offer a roadmap for future drug developers to better evaluate drug interactions.

Drug discovery efforts have expanded beyond the traditional approaches of small molecules and antibodies to include cells. This article explores the use of microfluidic methods for high-throughput screening of cell-based drug products.

Researchers discovered that ATP-sensitive potassium (KATP) channels in the brain play a pivotal role in sleep regulation. These energy sensors help maintain sleep-wake cycles and smooth transitions between them.

The complexity of the TME in vivo limits the conclusions that can be drawn from in vivo models. Optimizing cell culture models to mimic the TME is vital to understanding cancer progression and the development of optimized therapies.

New research shows that glucose regulates tissue differentiation by binding to hundreds of proteins throughout the cell to modulate their function and promote differentiation.