High-Throughput Screening – News and Features

Article
Fragment-Based Drug Discovery Enters the Mainstream
This article will discuss the principles of fragment-based drug discovery and will highlight some examples of recent successes in this area.

News
Could Existing Drugs Treat "Lincoln's Ataxia"?
Researchers have developed a new method to determine if FDA-approved drugs could be repurposed or improved to help patients with a rare disease of the nervous system, Spinocerebellar ataxia type 5.

Article
Cell Culture – Good Practice and Advanced Methods
This article will explore the importance of cell culture quality control and highlight recent developments in this area.

Industry Insight
Innovations and Versatility in Modern Microarray Technology
In this interview, CEO of Arrayjet Dr. Iain McWilliam discusses advancements in modern microarray technology and the benefits that these tools can provide for high-throughput screening.

Article
Towards the Lab of the Future
In this article, we look at the barriers preventing more widespread adoption of automation and digitization, and the opportunities they could bring.

Article
Target Identification and Validation in Drug Development
This article will highlight the properties of an attractive drug target, outline the approaches used to identify targets and discuss the key steps involved in target validation.

News
Neuronal "Housekeeping" Defects Linked to Huntington's Disease
A new study has identified how defects in the autophagy process in brain cells can lead to cell death that characterizes Huntington's disease.

Industry Insight
How CRISPR Is Transforming High-Throughput Screening
This article walks through the fundamentals of CRISPR screening and its most exciting applications, including unpicking cellular signaling networks, discovering how viruses like COVID-19 infect our cells and finding new drug targets.

News
AI Model Accurately Predicts Response to Novel Drug Compounds
Researchers have created an artificial intelligence model called CODE-AE that could significantly improve the accuracy, time and cost of the drug development process. Researchers hope this will accelerate drug discovery and precision medicine.

News
How a Metabolite Converts “Bad” Fat to “Good” Fat
Researchers used novel drug discovery technologies to uncover a metabolite that converts white fat cells (“bad” fat) to brown fat (“good” fat) cells. This discovery offers a potential way of addressing metabolic conditions like obesity, type 2 diabetes and cardiovascular disease.
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