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High-Throughput Screening – News and Features

Four different tablet types sit on or around a white puzzle piece.
Article

Fragment-Based Drug Discovery Enters the Mainstream

This article will discuss the principles of fragment-based drug discovery and will highlight some examples of recent successes in this area.
Different medications on a red background.
News

Could Existing Drugs Treat "Lincoln's Ataxia"?

Researchers have developed a new method to determine if FDA-approved drugs could be repurposed or improved to help patients with a rare disease of the nervous system, Spinocerebellar ataxia type 5.
Gloved hands hold an agar dish and a cotton swab. In the background other agar dishes and a test tube rack can be seen.
Article

Cell Culture – Good Practice and Advanced Methods

This article will explore the importance of cell culture quality control and highlight recent developments in this area.
Results of a cDNA microarray, reflecting the gene expression differences between two different tissues.
Industry Insight

Innovations and Versatility in Modern Microarray Technology

In this interview, CEO of Arrayjet Dr. Iain McWilliam discusses advancements in modern microarray technology and the benefits that these tools can provide for high-throughput screening.
A man wearing glasses with black frames looks through a screen with a digital overlay.
Article

Towards the Lab of the Future

In this article, we look at the barriers preventing more widespread adoption of automation and digitization, and the opportunities they could bring.
White and red pill cut in half showing a silver ball and stick molecular structure inside.
Article

Target Identification and Validation in Drug Development

This article will highlight the properties of an attractive drug target, outline the approaches used to identify targets and discuss the key steps involved in target validation.
Two images of brain cell clusters, one densely populated and the other sparsely populated.
News

Neuronal "Housekeeping" Defects Linked to Huntington's Disease

A new study has identified how defects in the autophagy process in brain cells can lead to cell death that characterizes Huntington's disease.
How CRISPR Is Transforming High-Throughput Screening content piece image
Industry Insight

How CRISPR Is Transforming High-Throughput Screening

This article walks through the fundamentals of CRISPR screening and its most exciting applications, including unpicking cellular signaling networks, discovering how viruses like COVID-19 infect our cells and finding new drug targets.
AI Model Accurately Predicts Response to Novel Drug Compounds content piece image
News

AI Model Accurately Predicts Response to Novel Drug Compounds

Researchers have created an artificial intelligence model called CODE-AE that could significantly improve the accuracy, time and cost of the drug development process. Researchers hope this will accelerate drug discovery and precision medicine.
How a Metabolite Converts “Bad” Fat to “Good” Fat content piece image
News

How a Metabolite Converts “Bad” Fat to “Good” Fat

Researchers used novel drug discovery technologies to uncover a metabolite that converts white fat cells (“bad” fat) to brown fat (“good” fat) cells. This discovery offers a potential way of addressing metabolic conditions like obesity, type 2 diabetes and cardiovascular disease.
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