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Neurogenomics – News and Features

A 3D model of a human brain.

Positive Life Linked to Mitochondria

Having more positive experiences in life is associated with lower odds of developing brain disorders like Alzheimer's disease and even a longer life. A study now suggests that the brain’s mitochondria may play a fundamental part.
A pregnant person in a yellow dress holds their bump.

Placental Immune Cells Reveal the Health of Fetal Brain Cells

The health of fetal macrophages in the placenta can act as an indicator of the health of fetal brain cells, reveals a new study.
A laptop screen with computer code in multiple colors.

Computational Method Links Molecular Marks on Our DNA to Gene Activity

Scientists have developed a computational method that links genes to the molecular marks on DNA that "switch" them on or off.
Cancer cells.

Potential Causes of Rare and Lethal Bone Cancer Identified

A team of researchers has recently published a genomic study that uncovered two classes of genetic causes for chordoma in children by conducting some genomic detective work.
A child looking through a toy.

Genetic Risk Factors for Autism Linked to Distinct Cellular Changes

A new single-cell study from the PsychENCODE initiative links genetic risk factors to cellular changes in ASD brains. The research, published in Science, provides insight on the potential causal mechanisms behind ASD.
A purple human brain.

Scientists Map the Genetic Regulatory Elements of the Brain

A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders.
A girl sitting on a chair looking out a window.

PTSD and Depression Have Shared and Distinct Brain Molecular Dysregulations

McLean Hospital researchers uncovered both shared and distinct molecular changes across brain regions, genomic layers, cell types and blood in individuals with posttraumatic stress disorder (PTSD) and major depressive disorder (MDD).

Clinical Trial Offers Promising Results for Alzheimer’s

A team evaluated a new drug for enhancing the brain’s resilience to changes driven by Alzheimer’s, showing promising results for patients with mild to moderate forms of the disease in its first human trial.
Mouse microglia flagged in red, the nuclei of other cells shown in blue and Hes1 activation shown in white.

Immune Reactions in Pregnant Mice Trigger Permanent Changes in Juvenile Brains

The immune response to viral infection during pregnancy affects the development of the unborn offspring, a new study in mice reveals.
A close up of someone's legs while running.

Exercise May Slow Cognitive Decline During Aging

University of Queensland research has found exercise can help prevent or slow cognitive decline during aging.