Next-Generation Sequencing – News and Features

Researchers have uncovered surprising ways transcription factors – the genetic switches for genes – regulate plant development, revealing how subtle changes in a lipid-binding region can dramatically affect growth.

An international study links GSK3B gene variants to autism and developmental delays. By analyzing 15 cases and using mouse models, researchers showed disrupted development in excitatory neurons.

New research suggests severe COVID-19 arises in part from the SARS-CoV-2 virus’s impact on mitochondria, which can help trigger a cascade of organ- and immune-system-damaging events.

The consumption of coffee has been linked to an increase in the bacterium Lawsonibacter asaccharolyticus.

University of Michigan researchers identified UBA1 as a key player in immunotherapy resistance. Inhibiting UBA1 boosts T-cell recruitment, converting cold tumors to hot, and enhancing the effectiveness of immune checkpoint blockade therapies.

A study uncovers that CD8+ T cells in ME/CFS patients exhibit exhaustion-like states, a condition linked to chronic immune activation. This discovery raises the possibility of adapting cancer immunotherapies to reverse T cell exhaustion in ME/CFS.

As muscles age, their cells lose the ability to regenerate and heal after injury. Researchers have created the most comprehensive picture yet of this process.

An international study analyzing Early Neolithic DNA uncovers a lack of social stratification among farmers in Central Europe 8,000 years ago. Findings reveal egalitarian practices in diet, grave goods, and origins.

A novel CAR T-cell therapy has benefitted patients with relapsed acute lymphoblastic leukemia, showing high response rates in a Phase Ib/II trial.

Researchers discovered that starlet sea anemones reshape their entire bodies during regeneration to maintain their original proportions. Using spatial transcriptomics, the team identified enzymes active throughout the body that realign tissues.