Spatial Biology – News and Features

New research has shown how brain cells acquire a cancerous mutation and spread across the cortex, opening a new path for early diagnosis and treatment.

VIB and KU Leuven researchers used spatial transcriptomics to map gene activity in motor neuron cell bodies and axons. In ALS models with FUS mutations, axons lost active Eif5a due to impaired hypusination, reducing local protein synthesis.

A newly developed immune cell atlas uses insights into how the immune system interacts with cancer cells to determine how aggressive a patient’s multiple myeloma is likely to be.

Researchers developed two computational tools to decode how cells communicate in tissues. sCCIgen creates realistic virtual tissues to test methods, while QuadST detects gene-level communication signals in real spatial transcriptomics data.

This article explores advances in both in vivo and ex vivo CAR T-cell therapies and discusses strategic development considerations that can reduce uncertainty and accelerate decision-making.

Researchers have uncovered a mechanism that allows breast cancer to send metastases to the brain, potentially enabling the development of new drugs.

New research reveals that bacteria inside tumors suppress the immune response, driving immunotherapy resistance in head and neck squamous cell carcinoma.

Disrupted circadian rhythms from night shifts, irregular sleep schedules or frequently flying across time zones can fuel breast cancer risk.

This article explores how single-cell multiomics and spatial transcriptomics are illuminating early pregnancy, uncovering maternal fetal cell interactions and paving the way for better understanding of reproductive health.

Scientists at MD Anderson Cancer Center discovered that the mitochondrial enzyme GFER promotes an immunosuppressive tumor environment in pancreatic cancer.