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Structural Biology – News and Features


Novel Antibiotic Hits Bacteria Twice, Making Resistance Nearly Impossible

A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago.
A scientist placing an LC vial onto carrousel of LC/MS to be analyzed.
Industry Insight

Meeting Complex Biopharma Analytical Needs

In this interview, Technology Networks spoke to Dr. Martin Vollmer, biopharma program manager within the Life Science Analysis Group at Agilent, to learn about the current analytical challenges the biopharma industry faces and how they are being addressed.

3D protein molecules showing the molecular backbone

An Introduction to Protein Purification: Methods, Technologies and Applications

The ability to obtain pure proteins is essential for developing drugs, creating vaccines and understanding biological processes. In this article, we discuss what a typical protein purification protocol involves and the various techniques used.
Three DNA helices

Scientists Capture a Key Step in Gene Transcription for the First Time

A new study has described E. coli RNAP in the act of opening the transcription bubble. The findings, captured within 500 milliseconds of RNAP mixing with DNA, shed light on fundamental mechanisms of transcription.
The 3D structure of a protein, with areas labelled in red, white and green.

New Insights Into the Evolution of Foldable Proteins

New research offers insights into the extensive relationship between exons in protein structures and the evolution of foldability.
A small molecule blocks the DNA splicing site of an enzyme.

Small Molecules Offer New Approach for Modulating Genetic Splicing

Researchers have uncovered how small molecules can modulate genetic splicing, offering a new approach to identifying drugs that act on genetic mutations.
Neurons degenerating.

Uncovering Hidden Pathways in Parkinson’s Disease Progression

A pair of recent studies have uncovered previously unknown cellular mechanisms involved in neuronal protein aggregation and misfolding, key characteristics of Parkinson’s disease.
Image from an electron microscope showing how Enterococcus faecalis bacteria clump together to share, among other things, antibiotic resistance with each other.

Understanding How Bacteria Share Antibiotic Resistance

A study provides new clues in the understanding of how antibiotic resistance spreads. The study shows how an enzyme breaks down the bacteria's protective outer layer, the cell wall, and facilitates the transfer of genes for resistance to antibiotics.
Antibodies fighting viruses.

Powerful Imaging Technique Shows How a Promising Antibody Neutralizes the Measles Virus

Researchers at LJI and Columbia University uncover exactly how a neutralizing antibody blocks measles virus infection
Neurons that look like cobwebs.

Novel PET Tracer Detects Parkinson’s Disease in Living Patients

Researchers from Japan have successfully developed a chemical radiotracer that binds to α-synuclein fibrils, harmful protein aggregates typically seen in PD and DLB pathologies.