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Structural Biology – News and Features

Protein structure.

Novel Method Reveals Tissue-Specific Protein Interactions

Researchers developed a novel chemical biology approach to label proteins from specific cells with a bifunctional amino acid probe that allows labelled proteins to be isolated and captures protein-protein interaction through photo-crosslinking.
This digitally-colorized, negative-stained transmission electron microscopic (TEM) image depicted a number of Influenza A virions.

Drug-Like Molecule Shows Promise in Preventing Flu Infection

Scripps Research scientists have developed a potential drug-like molecule that blocks the first stage of type A influenza infection. The drug-like inhibitors block the virus from entering the body’s respiratory cells.
Double helix structure of DNA.

Designing Peptoids That Mimic Nature’s Helices

Nature is filled with extraordinarily precise molecular shapes that fit together like a hand in glove. Proteins, for example, can assemble into a wide variety of well-defined shapes that grant them their function.
Microbes of different shapes, sizes and colors.

Climate Change May Threaten Freshwater Bacteria With Limited Adaptability

Freshwater bacteria crucial to ecosystem functioning may not be able to adapt quickly enough to survive climate change.
An NMR Spectrometer autosampler.

High Pressures Reveal Novel Structural Features in Proteins

3,000 bar of pressure reveals structural features of proteins that are too volatile to be observed under normal conditions.
A cell dividing.

Scientists Discover Protein Complex That Controls Cell Division

Researchers have discovered that how a special protein complex called the Mediator moves along genes in DNA may have an impact on how cells divide. The discovery may be important for future research into the treatment of certain diseases.
A cell dividing.

Researchers Track “Doubling” in Origin of Cancer Cells

Researchers have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer.
Bacteria bloom on a petri dish.

Bacteria Use a Protein Complex To Enhance Blockage of Phage Replication

The molecular assembly of a common anti-phage system employed by bacteria has been described in a new study.
Illustration of a human form

Dissecting the Proteome To Understand Disease

Proteomics provides insights into the regulation of biological processes and mechanisms of disease. In this article, we explore approaches scientists are using to find early markers of disease, new drug targets and strategies to overcome resistance to treatments.
A person sits next to a pile of photographs.

Memory Formation Mechanism Requires DNA Flexibility

Researchers have uncovered a novel mechanism underlying memory formation that involves rapid changes to DNA structure.