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Structural Biology – News and Features

Various pills on a table with a magnifying glass over one, bringing into focus.
Article

Drug Repurposing Strategies, Challenges and Successes

In this article, we explore the evolution of drug repurposing from a serendipitous occurrence to a more formalized endeavor involving advanced computational approaches and bioengineered test beds, considering its advantages, challenges and successes.
A mitochondria cut in half.
News

Leaky Mitochondria May Be Drivers of Inflammation

Researchers have discovered how “leaky” mitochondria – the powerhouses of our cells – can drive harmful inflammation responsible for diseases such as lupus and rheumatoid arthritis.
A prescription pill bottle spills tablets of different sizes, shapes and colors.
News

Existing Drugs Show Early Promise for Lowe Syndrome

A new treatment method that combines two existing drugs has shown early promise for treating Lowe syndrome.
A selection of pills and capsules in different shapes and colors.
News

Streamlined Drug Discovery Approach Proposed by Researchers

New research points to a streamlined approach to drug discovery that allows drug makers to determine the viability of a fragment-based design earlier in the process.
A COVID-19 virus.
News

Why Is the SARS-CoV-2 Virus Spherical in Shape?

One small protein in SARS-CoV-2, the Membrane protein, or M protein, is the most abundant and plays a crucial role in how the virus acquires its spherical structure. Nonetheless, this protein’s properties are not well understood.
An illustration of sperm cells.
News

Target for Reversible, Non-Hormonal Male Birth Control Identified in Mice

Researchers from the Salk Institute have uncovered a protein complex that regulates gene expression during sperm production and discovered an oral non-hormonal drug that reversibly stops this process in mice, without obvious side effects.
A water drop splashes as it hits the water's surface.
News

First-Ever Atomic Freeze-Frame of Liquid Water

Researchers have, for the first time, "frozen" the motion of atoms in liquid water and isolated the energetic movement of electrons.
An alarm clock.
News

New Epigenetic Clocks Predict Biological Age More Robustly

Investigators unveil a new form of epigenetic clock – a machine learning model designed to predict biological age from DNA structure. The novel model distinguishes between genetic differences that slow and accelerate aging.
The crystal structure of a protein, with the path of an electron mapped out.
News

How Proteins Act as Electron Navigators

New research has shown how small atomic movements of a protein can guide an electron to its destination, which scientists could mimic in the search for more efficient solar cells.
Vaccine vials.
News

Vaccine Candidate Shows Promise Against Birth Defect-Causing Virus

An experimental mRNA vaccine against human cytomegalovirus (CMV), a common virus that can infect babies during pregnancy, elicited some of the most promising immune responses to date of any CMV vaccine candidate.
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