Structural Biology – News and Features

After decades of trial and error, a promising new target for Lyme disease is emerging, the lyme bacterial protein CspZ, which the bacteria use to evade detection from the body’s immune system.

New research illustrates how cells with defective mitochondria activate a special recycling system to eliminate damaged genetic material.

Scientists at La Trobe University have discovered how a diarrhoea-causing strain of bacteria uses “molecular scissors” to cut open and destroy gut cells, leading to severe illness and sometimes death.

Researchers from the University of Iowa have unveiled the structure of a protein that plays a key role in protecting DNA during replication. This discovery may lead to the development of drugs targeting DNA repair pathways in cancer cells.

A team developed the catGRANULE 2.0 ROBOT, a machine-learning algorithm to predict protein behavior linked to neurodegenerative diseases like ALS, Parkinson’s and Alzheimer’s. The algorithm identifies toxic protein clumps.

Researchers have developed a laboratory model that mimics the pathological aggregation of TDP-43, a key protein in ALS and frontotemporal dementia. The model, based on human cells, recapitulates TDP-43’s mislocalisation and aggregation.

Researchers have identified how haptoglobin and CD163 protect the body from oxidative damage from free hemoglobin by uncovering the structure of CD163 binding to the haptoglobin-haemoglobin complex.

This article explores how automation is transforming proteomics by streamlining proteoform analysis, boosting throughput and reducing errors.

When consumed in chili during pregnancy, beans may help lower one’s risk for gestational diabetes, according to new research.

ETH researchers discovered related structures in Asgard archaea and describe their structure. These experiments show that Asgard tubulins form very similar microtubules, albeit smaller than those in their eukaryotic relatives.