Structural Biology – News and Features

New research has illustrated why a promising cancer drug doesn't work against some breast cancers – and has offered insights for new drugs.

By combining and developing various microscopic and spectroscopic techniques, researchers have revealed triggers of programmed cell death.

Around 300,000 people die from hepatitis C every year. A new study is the first to map the protein complex that enables the virus to infect our cells, potentially paving the way for an effective vaccine.

Research teams are analyzing how proteins work together to enable our cells to both stick and move. The marker protein paxillin is at the center of their interest.

Researchers identified the nucleolar protein PQBP3 as key in linking aging to neurodegenerative diseases. The study shows PQBP3's relocation during cellular senescence disrupts nuclear membrane stability.

We spoke to physician–scientist Professor Pradipta Ghosh about what drove her to follow this career path, her current work, the value of and challenges faced by physician–scientists and advice for those who are considering following in her footsteps.

Researchers add new evidence to the emerging concept that "silent" mutations may have crucial consequences, showing how a synonymous mutation in one gene can significantly affect a neighboring gene, increasing its protein production.

Researchers predicted the 3D shapes of 70,000 viral proteins, revealing shared immune evasion strategies across animal and bacterial viruses. This discovery provides insights into viral-host interactions.

Harvard-led researchers revealed how herpes simplex virus (HSV) develops resistance to antiviral drugs through changes in protein dynamics, not just mutations at drug-binding sites.

In this interview, we spoke to Dr. Raquel Cuella Martin to learn about her research, her experiences working as an LGBTQIA+ researcher in STEMM and her advice for others beginning a STEMM career.