Therapeutic Antibodies – Multimedia

App Note / Case Study
Controlling the Half-Life of Pathological IgG and Therapeutic Antibodies
Various autoimmune diseases (e.g., myasthenia gravis) are mediated by IgG autoantibodies. To address this mechanism of autoimmunity, researchers are exploring the therapeutic use of FcRn inhibitors in an effort to decrease the pathogenesis of IgG and develop new therapies.

Infographic
Therapeutic Antibodies
In this infographic, we explore the pipeline of therapeutic antibody discovery, development and manufacturing, highlighting key advancements throughout.

Video
New Electron Microscopy Technique Could Shortcut Development of Vaccines and Antibody Therapies
Scientists at Scripps Research have devised a method that may be able to shortcut one of the big steps in modern vaccine development.

App Note / Case Study
Mannose Glycans Content Screening for Human-mAb Samples
Glycosylation refers to the formation of linkages with glycosyl groups, covalently attaching a carbohydrate to another molecule. Antibody glycosylation is critical due to the role carbohydrates play in modulating effector functions which affect safety and efficacy of therapeutic antibodies.

Listicle
Therapeutic Antibody Engineering: Past, Present and Future
Download this free listicle to learn more about the current scope and future prospects for therapeutic antibody engineering.

App Note / Case Study
Convenient Customization of Your Cation Exchange Analysis
Therapeutic monoclonal antibodies (mAbs) are highly heterogeneous molecules due to being composed of a large number of variants. When the variants are present in the pharmaceutical protein, it is possible their biological activity could be altered.

App Note / Case Study
Convenient and Reliable Analysis of Antibody–Drug Conjugates
Antibody–drug conjugates (ADCs) are monoclonal antibodies to which a cytotoxic small molecule drug is chemically linked. The structures of ADCs are more complex than their corresponding antibodies.

App Note / Case Study
Preparation of Buffers and Solutions for Therapeutic Antibody Analysis
Antibodies are subject to instability issues due to chemical and physical instabilities and these effects can change the pharmacokinetics of the antibody. For this reason, produced antibodies must be thoroughly tested before they can be applied for treatment of patients.

App Note / Case Study
Your Guide to Multiple Attribute Methodology (MAM)
In biotherapeutic process development, evaluating and tracking potential product quality attributes (PQAs) is crucial to ensure quality, safety, and efficacy.

App Note / Case Study
Your Guide to mAb Variants
Antibody-based derivatives have received increased attention as therapeutics in biopharmaceutical development because of their unique capacity to engage multiple molecular targets, engage immune effector cells or even penetrate tissues previously inaccessible to conventional mAbs.
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