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Therapeutic Delivery – Multimedia

App Note / Case Study

Using DSC to Characterize Thermotropic Phase Transitions in Lipid Bilayer Membranes

The basics of liposome sample preparation and DSC studies.
Assessment of the Anti-angiogenic Effect of VEGFR2 siRNA in Clonetics™ HUVEC using the Lonza 4D-Nucleofector™ System content piece image
Poster

Assessment of the Anti-angiogenic Effect of VEGFR2 siRNA in Clonetics™ HUVEC using the Lonza 4D-Nucleofector™ System

In the current study we have used siRNA targeting VEGFR2 as an example to study knockdown of VEGFR2 and subsequent inhibition of tube formation by HUVECs on Growth Factor Reduced Matrigel™ in a 96-well plate format. The same strategy can be used for screening and validating siRNA based inhibitors of the angiogenic process in vitro and thus could be of utility in anti-cancer screening strategies.
Video

Photocontrolled Polymerizations in Flow: Next Generation Material Synthesis

Thomas Junkers, Hasselt University, speaking at Flow Chemistry India 2015
Assessment of the efficiency of encapsulation of a fluorescent drug using Nanoparticle Tracking Analysis content piece image
Poster

Assessment of the efficiency of encapsulation of a fluorescent drug using Nanoparticle Tracking Analysis

This poster outlines an example where the methodology of Nanoparticle Tracking Analysis (NTA) is used to characterise nanoparticles for drug delivery purposes.
App Note / Case Study

Detecting the Presence of Anomolous Large Particles Within Powders Using Laser Diffraction Particle Size Analysis

In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.
Analysis of Polymers, Additives and Contaminates in Medical Devices using Pyrolysis-GCMS content piece image
Poster

Analysis of Polymers, Additives and Contaminates in Medical Devices using Pyrolysis-GCMS

Pyrolysis GC-MS is a standard technique used to analyze industrial polymers. This poster will show the use of multiple temperature ramps to analyze for additives and contaminants, in addition to polymer identification, in several medical devices.
App Note / Case Study

Understanding the Effect of Molecular Weight and Structure on the Performance Characteristics of Cellulose Derivatives using OMNISEC

This application note describes the analyses of a variety of aqueous (water-soluble) cellulose derivatives using the OMNISEC triple detection system and the subtle, yet distinct differences between these different derivatives that can be parsed out by the OMNISEC system.
App Note / Case Study

Assessing Drug Encapsulation Efficiency using Nanoparticle Tracking Analysis

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
Liposomes and Nanoparticles as Delivery Vehicles for the Treatment of Lung Diseases content piece image
Poster

Liposomes and Nanoparticles as Delivery Vehicles for the Treatment of Lung Diseases

Targeted nanoparticle-based drug delivery to the lungs is an emerging area of interest for both scientists and medical workers because it allows better drug retention in the lungs and can provide prolonged drug release. In our study we investigated the potential of using liposomes and polymeric nanoparticles surface modified with a specific antibody as drug carriers for targeted drug delivery to the lungs.
Print Nanoparticle Vaccine Carrying Bacterial Polysaccharide And Protein Antigens  Induces Enhanced B- And T-Cell (Il-17) Immunity content piece image
Poster

Print Nanoparticle Vaccine Carrying Bacterial Polysaccharide And Protein Antigens Induces Enhanced B- And T-Cell (Il-17) Immunity

Antigenic multivalent PRINT nanoparticle formulations leverage precise control of size, shape and composition, sterile filterability and scalable cGMP roll-to roll manufacturing to offering a low cost and simplified manufacturing advantage over traditional conjugate vaccines.
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