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Therapeutic Delivery – Multimedia

Liposomes and Nanoparticles as Delivery Vehicles for the Treatment of Lung Diseases content piece image
Poster

Liposomes and Nanoparticles as Delivery Vehicles for the Treatment of Lung Diseases

Targeted nanoparticle-based drug delivery to the lungs is an emerging area of interest for both scientists and medical workers because it allows better drug retention in the lungs and can provide prolonged drug release. In our study we investigated the potential of using liposomes and polymeric nanoparticles surface modified with a specific antibody as drug carriers for targeted drug delivery to the lungs.
Print Nanoparticle Vaccine Carrying Bacterial Polysaccharide And Protein Antigens  Induces Enhanced B- And T-Cell (Il-17) Immunity content piece image
Poster

Print Nanoparticle Vaccine Carrying Bacterial Polysaccharide And Protein Antigens Induces Enhanced B- And T-Cell (Il-17) Immunity

Antigenic multivalent PRINT nanoparticle formulations leverage precise control of size, shape and composition, sterile filterability and scalable cGMP roll-to roll manufacturing to offering a low cost and simplified manufacturing advantage over traditional conjugate vaccines.
Next Generation Multivalent PRINT Nanoparticle Vaccine Targeting Pneumococcal Disease content piece image
Poster

Next Generation Multivalent PRINT Nanoparticle Vaccine Targeting Pneumococcal Disease

A new generation PRINT nanoparticle Pneumococcal vaccine matrix has been designed to mimic size and structural aspects of bacterial pathogens to efficiently present and deliver polysaccharide and protein antigens to elicit robust immune responses.
Video

Tumour Regression after Intravenous Administration of Novel Tumour-targeted Nanomedicines

In this talk, Christine Dufes demonstrates that the intravenous administration of a tumour-targeted dendriplex led to tumour disappearance of 90% of the tested tumours over one month.
Alternative Cellular Energy Based Therapy of Childhood Diarrhea content piece image
Poster

Alternative Cellular Energy Based Therapy of Childhood Diarrhea

Acute infectious diarrhea is a major cause of morbidity and mortality in the developing world; especially among children less than 5 years of age. As restoring normal cellular function is an energy-requiring process, patients with diarrhea could potentially benefit from receiving an alternative (non-mitochondria) source of cellular energy.
Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model content piece image
Poster

Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model

The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-ß-cyclodextrin (NC/HPßCD) and hydrophobic triacetyl-ß-cyclodextrin (NC/TAßCD), through the body for controlled drug delivery and sustained release have been examined.
Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model content piece image
Poster

Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model

The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-ß-cyclodextrin (NC/HPßCD) and hydrophobic triacetyl-ß-cyclodextrin (NC/TAßCD), through the body for controlled drug delivery and sustained release have been examined.
Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor content piece image
Poster

Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor

The objective of the present project is to develop transferrin coupled biodegradable nanoparticles (NPs) with high encapsulation efficiency (Doxorubicin). GALA (Glutamic acid-alanine-leucine alanine) a pH sensitive fusogenic endosomolytic peptide is added to the formulation to enhance the endosomal lysis that will further potentiate the delivery of anticancer drug inside tumor cell as well as prevent loss of drug via endosomes.
Physiologically-based pharmacokinetic (PBPK) model for prediction of midazolam pharmacokinetics after intranasal administration in children content piece image
Poster

Physiologically-based pharmacokinetic (PBPK) model for prediction of midazolam pharmacokinetics after intranasal administration in children

Study predicts midazolam absorption and pharmacokinetics (PK) after intranasal (i.n.) administration in young children.
Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops content piece image
Poster

Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops

A serious disadvantage of ocular timolol therapy is the amount of drug getting into systemic circulation that adversely affects vital organ functions in elderly patients.
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