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Western Blot – News and Features

Monoclonal vs Polyclonal Antibodies
Article

Monoclonal vs Polyclonal Antibodies

Antibodies are immunological proteins that play fundamental roles in host defense against infectious agents such as viruses, bacteria and fungi. Two types of antibodies – polyclonal and monoclonal – provide research scientists with distinct ways to detect or quantify target antigens largely due to differences in specificity and affinity. In this article, we describe polyclonal and monoclonal antibodies in more detail and consider how each type may be used for various applications.
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Article

Western Blot Procedures, Analysis and Purpose

There are many reasons you may need to determine the presence (or absence) and size of a given protein within a sample, potentially against a background of many others. The western blot is one such technique that offers these capabilities. In this article, we discuss what western blots are, how they are performed, what they show us and how they differ to related techniques.
Testing Blood Levels of ACE2 Species Could Help To Monitor SARS-CoV-2 Infection content piece image
News

Testing Blood Levels of ACE2 Species Could Help To Monitor SARS-CoV-2 Infection

A blood test that quantifies the protein ACE2, the cellular protein which allows entry of the virus into cells, as well as ACE2 fragments, produced as a result of interaction with the virus, could be an effective method for monitoring SARS-CoV-2 infection.
European Proteomics Infrastructure Consortium – Providing Access content piece image
Article

European Proteomics Infrastructure Consortium – Providing Access

The European Proteomics Infrastructure Consortium providing Access, or EPIC-XS, started in January 2019. It brings together a consortium of world-leading, highly innovative European proteomics facilities with the shared goal of supporting excellent life sciences research in Europe. In this article, Martina O'Flaherty provides an overview of some of the successes of the consortium so far.
The Importance of Automated Solutions for Laboratory Experiments   content piece image
Industry Insight

The Importance of Automated Solutions for Laboratory Experiments

Technology Networks recently spoke with Jean-François Bellec, ProteinSimple applications scientist, to learn about Bio-Techne’s history and how its solutions enable researchers to work efficiently and ensure accuracy in their experiments. In this interview, Jean-François also highlights how the company’s offerings have supported researchers throughout the COVID-19 pandemic.
Amyloid Protein Link Identified Between Melanoma and Parkinson's content piece image
News

Amyloid Protein Link Identified Between Melanoma and Parkinson's

It is recognized that Parkinson's disease patients are more likely to develop melanoma than the general population. Scientists now report a molecular link between the two diseases in the form of protein aggregates known as amyloids.
Variations in Herpes Infection Symptoms May Be Linked to Gene Expression Differences content piece image
News

Variations in Herpes Infection Symptoms May Be Linked to Gene Expression Differences

A new study finds that differences in the symptoms of herpes could be due to variations in the way certain strains of herpes simplex (HSV-1) – the virus that causes cold sores, as well as genital herpes – activate gene expression in neurons.
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Industry Insight

An Automated Age for Western Blotting

Western blotting has been a core technique in molecular biology for many years, however, optimization and reproducibility can be problematic. We spoke to Dr Alexandre Lucas about the automation of western blotting and the difference this advance is making to research.
Short Form of ACE2 Upregulated by Interferon Therapy Lacks SARS-CoV-2 Binding Site content piece image
News

Short Form of ACE2 Upregulated by Interferon Therapy Lacks SARS-CoV-2 Binding Site

Researchers have discovered a novel, short isoform of the protein angiotensin-converting enzyme 2 (ACE2). The study shows that although interferon therapy increases levels of ACE2 – the receptor used by SARS-CoV-2 to gain entry inside human cells – it largely increases levels of a shorter isoform. This isoform lacks high-affinity binding sites for SARS-CoV-2’s spike (S) glycoprotein, meaning the virus is unable to associate with it.
Diagnostic Marker May Help Predict Response to Cervical Cancer Treatment  content piece image
News

Diagnostic Marker May Help Predict Response to Cervical Cancer Treatment

A new diagnostic marker has been discovered by scientists that can predict the response to therapeutic treatments of patients with cervical cancer.
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