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Western Blot – News and Features

Protein structures alongside a human figure.
Article

Proteomics: Principles, Techniques and Applications

Proteomics is the study of the proteome—investigating how different proteins interact with each other and the roles they play within the organism. This comprehensive article reviews the principles of proteomics, technologies adopted to study the proteome, and the applications of this research field.
“Switch” Improves Control of Research's Old Detection Friends content piece image
News

“Switch” Improves Control of Research's Old Detection Friends

Streptavidin and biotin, form a very strong and specific interaction that is invaluable for many biotechnological applications used in science and medicine.
Accelerated Screen Identifies 25 Existing Drugs Capable of Disrupting SARS-CoV-2 Cell Entry content piece image
Industry Insight

Accelerated Screen Identifies 25 Existing Drugs Capable of Disrupting SARS-CoV-2 Cell Entry

A team from the National Center for Advancing Translational Sciences (NCATS) has screened existing drug compounds that have already passed through the entire drug development pipeline, to determine if any can disrupt the interaction between the SARS-CoV-2 spike protein and the host’s angiotensin converting enzyme 2 (ACE2) receptor.
Cashew Nut Compound Promotes Myelin Repair in MS Model content piece image
News

Cashew Nut Compound Promotes Myelin Repair in MS Model

In a new study by researchers at Vanderbilt University Medical Center, a chemical compound known as anacardic acid – found in the shell of cashew nuts – promotes the repair of myelin in animal models of multiple sclerosis (MS).
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Article

Using Protein Degradation To Target the Undruggable

This article explores the mechanism of ubiquitin-mediated proteasome-dependent degradation and how it has been employed to design novel therapeutics that can turn any class of human proteins into a therapeutic target.
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Industry Insight

Developing the World's First Single Molecule Protein Sequencer

Jagannath Swaminathan is the co-founder of Erisyon and a researcher at the Marcotte Lab at the University of Texas Austin. In this interview, we discuss the concept of next-generation protein sequencing, clinical proteomics and the critical role of protein sequencing in the fight against COVID-19.
How FAIMS Is Changing the Game in Proteomics content piece image
Article

How FAIMS Is Changing the Game in Proteomics

Scientists explore proteomes to identify proteins, quantify their expression and analyze modifications. But proteome coverage and complexity are increasing, creating challenges for traditional profiling. Technologies based on high-resolution mass spectrometry, however, can overcome this, making them the method of choice in basic, translational and biopharmaceutical laboratories alike.
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Article

Cancer Biomarkers: Powering Precision Medicine

Researchers are developing biomarker tests to detect cancer early, monitor therapeutic efficacy and predict outcomes – making diagnosis and treatment more precise.
The Pursuit of Spotting and Steering Cell Death   content piece image
Article

The Pursuit of Spotting and Steering Cell Death

Here, we examine one common branch of cell death, apoptosis, and explain why studying aberrations in apoptotic signaling is important for understanding and addressing a range of human pathologies. We also highlight techniques that enable studies of apoptosis.
Who Will Win the "Race to the Bottom" in the Infectious Disease Testing Market?  content piece image
Article

Who Will Win the "Race to the Bottom" in the Infectious Disease Testing Market?

When it comes to testing for infectious diseases, it seems some companies are engaged in a “race to the bottom” to provide the cheapest test possible. Ever-lower price points might be attractive for cash-strapped governments, NGOs and charities engaged in the ongoing fight against infectious diseases, but are such practices putting us at risk of compromising quality?
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