New Methods for RNA Modification Detection and Structure Probing

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RNA modifications play crucial roles in gene regulation, cellular function and the response to environmental stimuli. However, the detection and characterization of these modifications remain challenging due to the lack of tools and the high diversity of modification types.

Recent advancements in next-generation sequencing technologies have provided powerful tools for RNA modification detection, yet these methods often lack the sensitivity and specificity needed to capture the full spectrum of RNA modifications.

In this webinar, you’ll hear from three experts in the field about their research into the structure, function, regulation and detection of RNA modifications.

Attend this webinar to:

Explore how RNA modifications are linked to disease and could lead to new therapeutics
Discover the latest advancements in RNA modification detection technology
Compare and address the challenges of natural and synthetic RNA modification detection
Analyze the role and importance of reverse transcriptase enzymes in RNA modification detection

• Explore how RNA modifications are linked to disease and could lead to new therapeutics • Discover the latest advancements in RNA modification detection technology • Compare and address the challenges of natural and synthetic RNA modification detection • Analyze the role and importance of reverse transcriptase enzymes in RNA modification detection RNA modifications play crucial roles in gene regulation, cellular function and the response to environmental stimuli. However, the detection and characterization of these modifications remain challenging due to the lack of tools and the high diversity of modification types. Recent advancements in next-generation sequencing technologies have provided powerful tools for RNA modification detection, yet these methods often lack the sensitivity and specificity needed to capture the full spectrum of RNA modifications. In this webinar, you’ll hear from three experts in the field about their research into the structure, function, regulation and detection of RNA modifications. RNA modifications play crucial roles in gene regulation, cellular function, and the response to environmental stimuli. However, the detection and characterization of these modifications remain challenging due to the lack of tools and the high diversity of modification types. Recent advancements in next-generation sequencing technologies have provided powerful tools for RNA modification detection, yet these methods often lack the sensitivity and specificity needed to capture the full spectrum of RNA modifications. In this webinar, Philip Bevilacqua, PhD, Distinguished Professor of Chemistry and of Biochemistry & Molecular Biology, Penn State University, will provide an overview of recent advances in his lab. Sigrid Nachtergaele, PhD, Assistant Professor of Molecular, Cellular, and Developmental Biology, Yale University, will discuss her current work on understanding the regulation and functions of modifications on RNA, particularly mRNA and lncRNA. Also in this webinar, Anthony Mustoe, PhD, Assistant Professor of Biochemistry & Molecular Pharmacology, Baylor College of Medicine, will discuss his lab’s work developing new chemical probing strategies for measuring RNA structure and dynamics inside of living cells. Dr. Philip Bevilacqua Distinguished Professor of Chemistry and of Biochemistry & Molecular Biology Pennsylvania State University Dr. Sigrid Nachtergaele Assistant Professor of Molecular, Cellular, and Developmental Biology Yale University Dr. Anthony (Tony) Mustoe Assistant Professor of Biochemistry & Molecular Pharmacology Baylor College of Medicine

Speakers

Dr. Anthony Mustoe

Assistant Professor of Biochemistry & Molecular Pharmacology

Baylor College of Medicine

Dr. Mustoe is an Assistant Professor in the Therapeutic Innovation Center (THINC) and the Departments of Biochemistry and Molecular Pharmacology and Molecular and Human Genetics at Baylor College of Medicine. He is also a member of the Dan L Duncan Comprehensive Cancer Center. He is fascinated by how RNA sequences encode biology and in developing experimental and computational technologies to understand the biochemical mechanisms underpinning RNA function. His work has been recognized with CPRIT Scholar, Beckman Young Investigator, and Arnold O. Beckman Postdoctoral Fellowship awards. Prior to starting his own lab, he was a postdoctoral fellow in Kevin Weeks' lab in the Department of Chemistry at UNC Chapel Hill, where he helped develop single-molecule correlated chemical probing as a new strategy for measuring RNA structure and dynamics in living cells. He also helped lead one of the first large-scale efforts to define mRNA structures in living cells and their roles in regulating translation. Dr. Mustoe completed his Ph.D. in Biophysics in from the University of Michigan, where he worked with Charles Brooks III and Hashim Al-Hashimi to develop molecular dynamics methods to understand the forces driving RNA folding. He completed my undergraduate studies at Washington University in St. Louis, graduating in 2009 with degrees in Chemical Engineering and Mathematics. Dr. Mustoe is a native of Evanston, IL.

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Assistant Professor of Biochemistry & Molecular Pharmacology

Baylor College of Medicine

Dr. Philip Bevilacqua

Distinguished Professor of Chemistry and of Biochemistry & Molecular Biology

Pennsylvania State University

Phil graduated from North Collins High School in 1983. His undergraduate degree was from John Carroll University where he majored in Chemistry and minored in Physics, graduating in 1987. He obtained his Ph.D. at the University of Rochester in 1993 where he developed fluorescence-detected stopped-flow techniques for RNA secondary and tertiary structure formation. His postdoctoral studies were at the University of Colorado, where he was a Jane Coffin Childs Postdoctoral fellow. There he worked on the then newly discovered dsRNA-binding domain and elucidated determinants of its substrate specificity. In 1997 he joined the faculty of the Department of Chemistry at Penn State University as an Assistant Professor of Chemistry. In 2003 he was promoted with tenure to Associate Professor of Chemistry and in 2007 he was promoted to Full Professor of Chemistry. In 2015 he obtained a partial appointment as Professor of Biochemistry & Molecular Biology. He is a co-founder of the Center for RNA Molecular Biology at Penn State and is active in several interdepartmental graduate programs at Penn State including Plant Biology, Molecular Cellular and Integrative Biosciences (MCIBS), and Bioinformatics and Genomics. Beginning with his graduate work, through his post-doc, and into his independent career, Phil has focused on obtaining molecular insights into the myriad roles of RNA in biology through mechanistic approaches. The Bevilacqua lab has diverse interests in RNA that include ribozyme mechanism, pathways for RNA folding in vivo, RNA structure in living organisms, and roles for RNA on early Earth. His lab has introduced new approaches to study RNA, often in a collaborative fashion, including pKa measurements by diverse means; use of conformationally restricted nucleotides to probe RNA structure and function; probing of RNA folding across an entire transcriptome in vivo; and compartmentalizing and studying RNA function.

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Distinguished Professor of Chemistry and of Biochemistry & Molecular Biology

Pennsylvania State University

Dr. Sigrid Nachtergaele

Assistant Professor of Molecular, Cellular, and Developmental Biology

Yale University

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Applied Sciences

Applied Sciences

New Methods for RNA Modification Detection and Structure Probing