Latest App Notes & Case Studies

This app note presents a comprehensive overview of Raman spectroscopy applications for real-time, in-line monitoring of downstream bioprocesses, exploring methods for accurate protein quantification and structural analysis and buffer assessment.

This application note highlights a streamlined approach to AAV serotype filtration, showcasing rapid processing, high recovery and scalability.

Process monitoring from raw materials to finished products in biopharmaceutical industry

This application note demonstrates how a mixed-mode resin can help to achieve aggregate reduction targets (<2%) with high monomer recovery and simultaneous removal of 95% HCPs at high loadings in flow-through mode, increasing productivity in manufact

This technical note explores a novel poly(A) tail modification that enhances total protein expression and extends expression duration across multiple constructs and cap structures, without increasing immune response.

This application note explores how an advanced 5 L single-use bioreactor enhances productivity, reduces costs and enables seamless scalability from bench to production.

This case study highlights how optimized cell culture media and feed systems simplify scale-up, reduce risk and deliver consistent results across production volumes.

This application note presents a live-cell, no-wash assay using a pH-sensitive Fab-based labeling dye to quantify internalization events as antibodies traffic to acidic compartments.

This application note explores how advanced SFM formulations can dramatically improve CRISPR-modified CAR-T cell production while maintaining GMP compliance and scalability.

This app note details the application of advanced flow-through chromatography techniques, with case studies and practical guidance demonstrating how researchers can overcome complex polishing challenges to achieve high product quality and process eff