Latest Application Notes
A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum
RTP004 is a proprietary peptide used by Revance Therapeutics as a novel excipient in DaxibotulinumtoxinA for injection. Due to its high molecular weight, high isoelectric point and strong non-specific binding property, the sample preparation and LC-MS method development for this peptide is very challenging.
Microflow Chromatography: A Key to More Sensitive Metabolite Identification
In early-stage pharmaceutical research, knowledge of a compound’s metabolism can assist in the identification of structural liabilities that can contribute to non-optimal pharmacokinetics, potentially toxic breakdown products or the potential for drug-drug interactions.
Achieve Next Level Sensitivity for the Evolution of Routine Bioanalysis
Sample preparation and alternative chromatography techniques are often used to meet the sensitivity needs required in routine bioanalytical assays, but these methods can be time consuming.
Cyclic Peptide Quantitation in Human Plasma
In biotherapeutic development, decreased drug doses and limited sample volumes require higher quantification sensitivity, while the complexity of biological matrices calls for the need of assay selectivity improvement.
Early Screening of Pancreatic Cancer Immunotherapy Target Candidates
It has proven difficult to accurately identify the biological targets of cancer, which are necessary for the development of successful therapeutics including novel immunotherapies, such as those based on chimeric antigen receptor (CAR) T cells.
Accelerating Target Validation for Therapeutics With Engineered Cell Libraries
One approach to develop drugs for infectious diseases involves a comprehensive understanding of human-pathogen protein interactions, as targeting host proteins helps reduce the possibility of drug resistance by creating a more significant evolutionary barrier for the virus.
Top Five Reasons To Consider Fully-Automated Enzyme Assays
Download this app note to discover reasons why you should consider fully automated enzyme analysis.
Gene Modification for Cell Therapy Applications
The clinical success of CAR T-cell therapy has spurred increased interest and investments in the advanced therapeutics industry.
Kinetic Curvature: Assessment of Small Molecule Kinetics and Affinity
Surface plasmon resonance (SPR) is a core technology used in many pharma and biotechnology settings for this purpose, however traditional initial SPR screening of weak affinity compounds using a single fixed concentration injection can present numerous challenges.
CRISPR Engineered Cells Enable Variant Disease Modeling
Comprehensive disease modeling can be challenging for many labs due to variations in reagents, cell culture conditions, technical inconsistencies across protocols and experiments and bandwidth limitations.