Latest App Notes & Case Studies

In biotherapeutic process development, evaluating and tracking potential product quality attributes (PQAs) is crucial to ensure quality, safety, and efficacy.

Antibody-based derivatives have received increased attention as therapeutics in biopharmaceutical development because of their unique capacity to engage multiple molecular targets, engage immune effector cells or even penetrate tissues previously inaccessible to conventional mAbs.

Download this app note to discover a system that demonstrates good chromatographic separation of nitrosamine compounds and provides enhanced sensitivity.

Shotgun proteomics has the capacity to deliver in-depth information on the identification, the relative amount, and the modification patterns of ever larger fraction of the proteins present in a sample. This has made it an essential approach in most biological research areas.

Target identification and characterization are key challenges in drug discovery and begin with identifying the function of a possible therapeutic target and its role in the disease.

The SARS-CoV-2 spike protein has rightly garnered attention as a leading candidate for protein-based vaccines for COVID-19. Multiple studies have shown that neutralizing antibodies bind to the spike protein at both peptide and peptidoglycan epitopes.

The efficient monitoring of T-cell surface markers, cytokines and expression patterns is critical to the study of further immunotherapies. Download this app note to discover how cell analyzers can help.

Many people pursue ideas of “efficiency” as an ideal for daily life — ideas include how many tasks we can accomplish in a short time frame and how we can minimize our impact on the environment. The same can be true with high performance liquid chromatography (HPLC).

Cell culture can be a challenging process because cells are influenced by many factors including how they are physically handled and the labware used to seed and feed cultures.

Protein loss during sample preparation can be an obstacle to reliable product quantitation in all biopharmaceutical settings. Samples are often prepared from feedstocks containing insoluble particles and therefore require a solid-liquid separation before analysis to protect analytical instruments.