Latest Application Notes
A Novel Lipid Screening Platform that Provides a Complete Solution for Lipidomics Research
A novel lipidomics platform was developed that includes simplified sample preparation, automated methods, and streamlined data processing techniques that enable facile, quantitative lipid analysis.
Novel Chemical Standards Kits Enable Facile Lipid Quantitation
The Lipidyzer platform provides more accurate lipid analysis with less quantitative bias.
Accelerating Biotherapeutic Process Development Using Differential Scanning Calorimetry
This document illustrates how the technique can be used to examine the stability of individual domains in multi-domain proteins and guide process development for antibodies and other proteins.
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure and in understanding the factors that affect the function and the stability of antibodies.
Identification of Insulin Oligomeric States Using SEC-MALS
This application note shows how the combination of column chromatography (SEC/GPC) with MALS, DLS and RI detection can be applied as a powerful tool to identify monomers, dimers, hexamers and higher aggregates of insulin.
Charge and Interaction Analysis for Predicting Antibody Formulation Stability
Colloidal stability is a key solution property of a biotherapeutic formulations, indicative of long-term stability. As it is readily measured over much shorter time scales than long-term stability testing or even accelerated testing regimens, measurements of colloidal stability are often utilized in the course of formulation work to screen out poorly behaved conditions.
The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability
This experiment demonstrates that thermal and colloidal stability of proteins, two indicators of propensity to aggregate, as well as actual aggregation states, are all determined simultaneously during the screening process with dynamic light scattering (DLS) tools in order to rank the effectiveness of candidates and formulation conditions.
Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry
DSC data is useful in predicting the stability of a protein in solution. The Tm indicates thermostability, and Tm determination in different formulations is an approximate measure of the susceptibility to aggregation and other irreversible changes at lower temperatures.
Differentiation and characterization of subvisible particulates in therapeutic protein products
The formation of protein aggregates is a particular concern for parenteral administration biopharmaceuticals due to the potential for increased immunogenicity.