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Latest Application Notes
Preformulation and Stability Studies of Biotherapeutics Using DSC
Application Note

Preformulation and Stability Studies of Biotherapeutics Using DSC

The Malvern MicroCal VP-Capillary DSC has been used for rapid screening of buffers in preformulation development and for the optimization of storage conditions of antibodies during process development. The results correspond well with those obtained by other more time-consuming methods.
A Novel Lipid Screening Platform that Provides a Complete Solution for Lipidomics Research
Application Note

A Novel Lipid Screening Platform that Provides a Complete Solution for Lipidomics Research

A novel lipidomics platform was developed that includes simplified sample preparation, automated methods, and streamlined data processing techniques that enable facile, quantitative lipid analysis.
Novel Chemical Standards Kits Enable Facile Lipid Quantitation
Application Note

Novel Chemical Standards Kits Enable Facile Lipid Quantitation

The Lipidyzer platform provides more accurate lipid analysis with less quantitative bias.
Accelerating Biotherapeutic Process Development Using Differential Scanning Calorimetry
Application Note

Accelerating Biotherapeutic Process Development Using Differential Scanning Calorimetry

This document illustrates how the technique can be used to examine the stability of individual domains in multi-domain proteins and guide process development for antibodies and other proteins.
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Application Note

Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
Application Note

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies

The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure and in understanding the factors that affect the function and the stability of antibodies.
Identification of Insulin Oligomeric States Using SEC-MALS
Application Note

Identification of Insulin Oligomeric States Using SEC-MALS

This application note shows how the combination of column chromatography (SEC/GPC) with MALS, DLS and RI detection can be applied as a powerful tool to identify monomers, dimers, hexamers and higher aggregates of insulin.
Charge and Interaction Analysis for Predicting Antibody Formulation Stability
Application Note

Charge and Interaction Analysis for Predicting Antibody Formulation Stability

Colloidal stability is a key solution property of a biotherapeutic formulations, indicative of long-term stability. As it is readily measured over much shorter time scales than long-term stability testing or even accelerated testing regimens, measurements of colloidal stability are often utilized in the course of formulation work to screen out poorly behaved conditions.
The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability
Application Note

The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability

This experiment demonstrates that thermal and colloidal stability of proteins, two indicators of propensity to aggregate, as well as actual aggregation states, are all determined simultaneously during the screening process with dynamic light scattering (DLS) tools in order to rank the effectiveness of candidates and formulation conditions.
Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry
Application Note

Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry

DSC data is useful in predicting the stability of a protein in solution. The Tm indicates thermostability, and Tm determination in different formulations is an approximate measure of the susceptibility to aggregation and other irreversible changes at lower temperatures.
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