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Latest App Notes & Case Studies

App Note / Case Study

Controlling the Half-Life of Pathological IgG and Therapeutic Antibodies

Various autoimmune diseases (e.g., myasthenia gravis) are mediated by IgG autoantibodies. To address this mechanism of autoimmunity, researchers are exploring the therapeutic use of FcRn inhibitors in an effort to decrease the pathogenesis of IgG and develop new therapies.
App Note / Case Study

mAb Quantitation: Protein A HPLC vs Protein A Bio-Layer Interferometry

There are currently more than 140 monoclonal antibodies (mAbs) approved by the FDA as biotherapeutic agents, representing the most rapidly growing class of new drugs.
App Note / Case Study

Proteomics at the Single-Cell Level

Single-cell proteomics is a rapidly developing field with the potential to make important contributions to understanding cellular heterogeneity.
App Note / Case Study

From Mammalian Cell Cultures to Pure Proteins: Reduce Your Cell Harvest Time

For therapeutic applications, it is important that protein production from mammalian cell lines is efficient and pure.
App Note / Case Study

Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Preparation

Download this free application focus to learn more about how Agilent's latest RapidFire 400 mass spectrometry system.
App Note / Case Study

Get a High-Resolution View of Your Lipid Nanoparticles

Lipid nanoparticles (LNP) play a key role in effectively protecting and transporting mRNA to target cells in mRNA-based vaccines and therapeutics. To ensure the quality and safety of LNP, lipid components and associated impurities/degradants need to be carefully characterized in raw materials and formulation.
App Note / Case Study

Purification of Single-Stranded RNA Oligonucleotides Using High-Performance Liquid Chromatography

A crucial step in any pharmaceutical production is the purification of the product. The purification of oligonucleotides (ONs) can be particularly challenging because of the high similarity of target and impurities.
App Note / Case Study

Recent Developments in Covid Virology

COVID-19 is caused by the SARS-CoV-2 virus. While some patients have mild or asymptomatic illness, for others it can be fatal. Understanding the immune response to SARS-CoV-2 at a molecular level is useful for the development of effective vaccines, treatments and prognostic tests.
App Note / Case Study

Is This Europe’s Most Modern Biobank?

The University of Szeged is one of Hungary’s leading research institutions with a long history of pioneering scientific achievements. For generations, the university’s scholars have been focused on collecting and storing biological samples for educational purposes as well as for clinical, biomedical and physiological research.
App Note / Case Study

Cold Activation of TRPM8 Using a temperature controlled External Perfusion System and the Port-a-Patch

Download this app note to learn more about how TRPM8 channels have been implicated to play a role in cancer, in particular prostate and pancreatic cancer.
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